|Table of Contents|

The function and significance of Apaf-1 in the treatment of breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
981-984
Research Field:
Publishing date:

Info

Title:
The function and significance of Apaf-1 in the treatment of breast cancer
Author(s):
Liu Zhuo1Li Xiaofeng2Ba Caixia3Zhang Meiyun2
1.Baotou Medical College,Inner Mongolia Baotou 014040,China;2.Department of Medical Oncology;3.Department of Gynecologic Oncology,Baotou Cancer Hospital,Inner Mongolia Baotou 014030,China.
Keywords:
Apaf-1breast cancerapoptosis
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.06.041
Abstract:
Neoadjuvant chemotherapy for breast cancer can not only reduce the clinical stage,improve the rate of breast conserving surgery,but also determine the sensitivity of chemotherapy drugs,and guide chemotherapy drugs,has gradually become the first choice for the treatment of breast cancer.AI (apoptotic index) is the key factor to evaluate the efficacy of neoadjuvant chemotherapy for breast cancer,and Apaf-1 is an important member of the apoptosis pathway,which plays an important role in apoptosis.This article reviews the role of Apaf-1 in the treatment of breast cancer with the combination of AI,the structure,distribution and expression of Apaf-1 and the expression of chemotherapy drug resistance.

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Last Update: 2017-01-26