[1]Fan L,Strasser Weipplk,Li JJ,et al.Breast cancer in China[J].Lancet Oncol,2014(7):e279-289.
[2]Chen JL,Fu YY.Apaf- 1 and apoptosis[J].Foreign Medical Sci Physiol Pathol,2001,8(2):95-97.[陈剑琳,傅宇阳.Apaf- 1和凋亡[J].国外医学生理病理科学与临床分册,2001,8(2):95-97.]
[3]Yuan S,Topf M,Reubold TF,et al.Changes in Apaf-1 conformation that drive apoptosome assembly[J].Biochemistry,2013,52:2319-2327.
[4]Pang Y,Bai XC,Yan C,et al.Structure of the apoptosome:Mechanistic insights into activation of an initiator caspase from Drosophila[J].Genes Dev,2015,29:277-287.
[5]Reubold TF,Eschenburg S.A molecular view on signal transduction by the apoptosome[J].Cell Signal,2012,24:1420-1425.
[6]Zamzami N,Hirsch T,Dallaporta B,et al.Mitochondrial implicationin accidental and programmed cell death:Apoptosis and necrosis[J].J Bioenerg Biomembr,1997,29(2):185-193.
[7]Green DR,Kroemer G.The pathophysiology of mitochondrial celldeath[J].Science,2004,305(5684):626-629.
[8]Zhang BX,Zhang JK,Chen X,et al.Clinical significance of Apaf-1 protein expression in basal cell like breast cancer[J].Chin Tropical Med,2014,14(9):1096-1098.[张丙信,张金库,陈雪,等.基底细胞样乳腺癌组织Apaf-1蛋白表达临床意义[J].中国热带医学,2014,14(9):1096-1098.]
[9]Ma YG,Lou Y,Zhao HR.Apaf-1 expression and promoter methylation in non small cell lung cancer[J].Chin J Oncol,2006,13(2):116-119.[马业罡,娄毅,赵惠儒.非小细胞肺癌组织中Apaf-1基因表达及启动子区甲基化研究[J].中华肿瘤防治杂志,2006,13(2):116-119.]
[10]Dong MM.Expression and clinical significance of Apaf-1 gene in hepatocellular carcinoma[D].Hubei:Huazhong University of Science and Technology,2010.[董明明.Apaf-1基因在肝细胞肝癌中的表达和临床意义[D].湖北:华中科技大学,2010.]
[11]Liu Z,Zhang CW,Wang C.Methylation and expression of Apaf-1 gene in the occurrence of colorectal cancer[J].J Qinghai Med College,2010,31(1):18-23.
[12]Ottosson-Wadlund A,Ceder R,Preta G,et al.Requirement of apoptotic protease activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells[J].Mol Pharmacol,2013,83:245-255.
[13]Soengas MS,Capodieci P,Polsky D,et al.In activation of the apoptosis effect or Apaf-1 in malignant melanoma[J].Nature,2001,409(6817):207-211.
[14]Fu WN,Bertoni F,Kelsey SM,et al.Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia[J].Oncogene,2003,22(3):451-455.
[15]Liu XJ,Sun QF,Bian LG,et al.Promoter region methylation of -1 gene promoter and expression of mRNA gene in pituitary adenoma[J].Chin J Minimally Invasive Neurosurgery,2009,14(4):183-186.[刘先进,孙青芳,卞留贯,等.垂体腺瘤凋亡蛋白酶活化因子-1基因启动子区甲基化与其mRNA表达[J].中国微侵袭神经外科杂志,2009,14(4):183-186.]
[16]Guo J.The significance of Apaf-1 gene promoter methylation and expression of anti apoptotic protein Apollon in adult acute leukemia[D].Shandong:Shandong University,2011.[郭军.Apaf-1基因启动子甲基化与抑凋亡蛋白Apollon表达在成人急性白血病发生发展中的意义[D].山东:山东大学,2011.]
[17]Ma HL,Guo W,Guo YL,et al.Methylation status of apoptotic protease activating factor-1 gene in gastric cardia adenocarcinoma and its clinical significance[J].Chin J Cancer and Biol Therapy,2012,19(5):526-530.[马洪亮,郭炜,郭艳丽,等.凋亡蛋白酶活化因子-1基因在贲门腺癌中的甲基化状态及其临床意义[J].中国肿瘤生物治疗杂志,2012,19(5):526-530.]
[18]Cecconi F,Alvarez-Bolado G,Meyer BI,et al.Apaf1(CED-4homolog)regulates programmed cell death in mammalian development[J].Cell,1998,94:727-737.
[19]Yoshida H,Kong YY,Yoshida R,et al.Apaf1 is required for mitochondrial pathways of apoptosis and brain development[J].Cell,1998,94:7392-7750.
[20]Zlobec I,Minoo P,Baker K,et al.Loss of Apaf-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer[J].Eur J Cancer,2007,43(6):1101-1107.
[21]Anichini A,Mortarini R,Sensi M,et al.Apaf-1 signaling in human melanoma[J].Cancer Lett,2006,238(2):168-179.
[22]Perkins C,Kim CN,Fang G,et al.Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel-or etopside treated HL-60 cells[J].Cancer Res,1988,58(20):4561-4566.
[23]Benites BD,Fattori A,Hackel C,et al.Low expression of Apaf-1XL in acute myeloid leukemia may be associated with the failure of remission induction therapy [J].Braz J Med Biolres,2008,41(7):571-578.
[24]Li HM,Yang YS,Cheng LF.Transfection of Apaf-1 gene and its effect on the apoptosis of AGS cells induced by 5-FU[J].Chin J Digestion,2002,22(9):550-553.[李红梅,杨云生,程留芳.Apaf-1基因转染及其对5-氟尿嘧啶诱导AGS细胞凋亡的影响[J].中华消化杂志,2002,22(9):550-553.]
[25]Zlobec I,Vuong T,Compton C.The predictive value of apoptosis protease-activating factor 1 in rectal tumors treated with preoperative,high-dose-rate brachytherapy[J].Cancer,2006,106(2):284-286.
[26]Cheng L,Xia TS,Wang YF,et al.The anticancer effect and mechanism of α-hederin on breast cancer cells[J].Int J Oncol,2014,45:757-763.
[27]Sun JP,Liu JH,Gu H,et al.Effect of arsenic trioxide on the expression of Apaf-1 gene in bladder cancer T24 cells[J].Carcinogenesis,Teratogenesis and Mutagenesis,2013,25(5):338-342.[孙军培,刘久华,顾恒,等.三氧化二砷对膀胱癌T24细胞Apaf-1基因表达的影响[J].癌变·畸变·突变,2013,25(5):338-342.]
[28]Tan L,Kwok RP,Shukla A,et al.Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells[J].Cancer,2011,117:784-794.
[29]Pierga JY,Mouret E,Lau rence V,et al.Prognotic factors for survival after neoadjuvant chemotherapy operable breast cancer.The role of clinical response [J].Eur J Cancer,2003,39(8):1089-1096.
[30]Liu ZY,Li BJ.Observation of the dynamic changes of circulating tumor cells in neoadjuvant chemotherapy of breast cancer[J].Clin Oncol China,2015,40(23):1431-1435.[刘志勇,李宝江.乳腺癌新辅助化疗中循环肿瘤细胞的动态变化及疗效观察[J].中国肿瘤临床,2015,40(23):1431-1435.]
[31]Berry DA,Cirrincione C,Henderson IC,et al.Estrogen receptor status and outcomes of modern chemotherapy for patients with node positive breast cancer[J].JAMA,2006,295(14):1658-1667.
[32]Sullivan PS,Apple SK.Should histologic type be taken into account when considering neoadjuvant chemotherapy in breast carcinoma[J]?Breast J,2009,15(2):146-154.
[33]Nishimura R,Osako T,Okumura Y,et al.Clinical significance ofKi-67 in neoadjuvant chemotherapy for primary breast cancer as a predictor for chemosensitivity and for prognosis[J]. Breast Cancer,2010,17(4):269-275.
[34]He Yuping,Xie Yuhui,Kuang Zhongsheng.The relationship between ER,PR,HER2,p53 and neoadjuvant chemotherapy efficacy[J].Guide of China Med,2012,12(2):401.
[35]Davis DW,Buchholz TA,Hess KR,et al.Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer:Early assessment predicts clinical response[J].Clin Cancer Res,2003,9(3):955-960.
[36]Ling R,Shi M,Zhang JL,et al.Changes of cell proliferation and apoptosis in breast cancer after neoadjuvant chemotherapy and its clinical significance[J].Chin J Oncol,2007,14(14):1085-1087.[凌瑞,石梅,张聚良,等.乳腺癌新辅助化疗后细胞增殖与凋亡的变化及临床意义[J].中华肿瘤防治杂志,2007,14(14):1085-1087.]
[37]Patil AV,Singhai R,Bhamre RS,et al.Ki-67 biomarker in breast cancer of Indian women[J].N Am J Med Sci,2011,3(3):119-128.
[38]Xie M,Chen JF,Liang H,et al.The value of cell apoptosis in prediction of neoadjuvant chemotherapy for breast cancer[J].Southern China National Medical J,2013,27(12):870-872.[谢明,陈建发,梁红,等.细胞凋亡对乳腺癌新辅助化疗的预测价值[J].华南国防医学杂志,2013,27(12):870-872.]
[39]Del Bello B,Valentini MA,Mangiavacchi P,et al.Role of caspase-3 and-7 in Apaf-1 proteolytic cleavage and degradation even ts during cisplatin-induced apoptosis in melanoma cells[J].Exp Cell,2004,293(2):302-310.
[40]Arpino G,Ciocca DR,Weiss H,et al.Predictive value of apoptosis,proliferation,HER-2,and topoisomerase II alpha for anthracy cline chemotherapy in locally advanced breast cancer[J].Breast Cancer Res Treat,2005,92(1):69-75.
[41]Fortin A,Cregan SP,MacLaurin JG,et al.APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death[J].J Cell Biol,2001,155:207-216.