|Table of Contents|

The preventable effects of the split course radiotherapy on radiation proctopathy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
852-855
Research Field:
Publishing date:

Info

Title:
The preventable effects of the split course radiotherapy on radiation proctopathy
Author(s):
He Xinying1Wang Shuwen2Chu Weiwei1Ma Jun2Zhang Long2Wang Cheng2
1.Department of Pathology,Xi'an Medical Univercity,Shaanxi Xi'an 710021,China;2.Department of Radiotherapy,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China.
Keywords:
the split courseradiotherapyradiation proctitis
PACS:
R730.55
DOI:
10.3969/j.issn.1672-4992.2017.06.004
Abstract:
Objective:To investigate the preventable effects of the split course radiotherapy on radiation proctopathy.Methods:Forty-five SD rats were randomly divided into nine groups.Group A:Nomal control group.Group B to group I:The rats were treated pelvic cavity with radiotherapy,DT 44Gy/(22f·30d),5f/w,6 weeks after treatment received a RT boost,DT 46Gy/(23f·31d),5f/w.Rectal mucosal changes were observed in d0,d30,d72,d86,d103,d143,d145,d159,d193 and d283 respectively under biopsy microscope.Results:Before,during and after radiotherapy,we observed the rectal mucosal inflammatory changes,repair,reinjury,repair,and no Ⅲ-Ⅳ grade radiation enteritis occurred.Conclusion:Given the radical dose,the split course radiotherapy can prevent severe proctitis,has potential clinical application value.

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Memo

Memo:
陕西省教育厅科学研究项目(编号:12JK0699);陕西省科学技术研究发展计划(编号:2011JM4038)
Last Update: 2017-01-26