|Table of Contents|

The relationship between type 2 diabetes and liver cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
819-822
Research Field:
Publishing date:

Info

Title:
The relationship between type 2 diabetes and liver cancer
Author(s):
Jiang Wen1Yang Mi2Xu Hanfeng1Zhang Quanan3
1.Department of Oncology,The Second Hospital Attached to Southeast University,Jiangsu Nanjing 210003,China;2.Cancer Center,Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School,Clinical Cancer Institute of Nanjing University,Jiangsu Nanjing 210008,China;3.Department of Oncology,The Affiliated Jiangning Hospital of Nanjing Medical University,Jiangsu Nanjing 211100,China.
Keywords:
type 2 diabeteshepatocellular carcinomaprognosis
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2017.05.040
Abstract:
Hepatocellular carcinoma (HCC) has a high incidence in China.Research has shown that,type 2 diabetes (T2DM) is related with the occurrence and development of HCC.Here is a summary of the relationship between HCC and T2DM.

References:

[1]Onitilo AA,Engel JM,Glurich I,et al.Diabetes and cancer I:risk,survival,and implications for screening[J].Cancer Causes Control,2012,23(6):967-981.
[2]Sánchez Peralta AM,Oliveras-López MJ,Pérez González R,et al.Prevalence of diabetes in a cancer population in a Malaga hospital[J].Nutr Hosp,2012,27(2):456-462.
[3]Zanders MM,Vissers PA,Haak HR,et al.Colorectal cancer,diabetes and survival:epidemiological insights[J].Diabetes Metab,2014,40(2):120-127.
[4]Raff EJ,Kakati D,Bloomer JR,et al.Diabetes mellitus predicts occurrence of cirrhosis and hepatocellular cancer in alcoholic liver and non-alcoholic fatty liver diseases[J].J Clin Transl Hepatol,2015,3(1):9-16.
[5]Wang P,Kang D,Cao W,et al.Diabetes mellitus and risk of hepatocellular carcinoma:a systematic review and Meta-analysis[J].Diabetes Metab Res Rev.2012,28(2):109-122.
[6]Arase Y,Kobayashi M,Suzuki F,et al.Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C[J].Hepatology,2013,57(3):964-973.
[7]Li CI,Chen HJ,Lai HC,et al.Hyperglycemia and chronic liver diseases on risk of hepatocellular carcinoma in Chinese patients with type 2 diabetes-National cohort of Taiwan Diabetes Study[J].Int J Cancer,2015,136(11):2668-2679.
[8]Barone BB,Yeh HC,Snyder CF,et al.Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus:a systematic review and meta-analysis[J].JAMA,2008,300(23):2754-2764.
[9]Hassan MM,Curley SD,Kaseb A,et al.Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma[J].Cancer,2010,116(8):1938-1946.
[10]Schlesinger S,Aleksandrova K,Pischon T,et al.Diabetes mellitus,insulin treatment,diabetes duration,and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort[J].Ann Oncol,2013,24(9):2449-2455.
[11]Zhang PH,Chen ZW,Lv D,et al.Increased risk of cancer in patients with type 2 diabetes mellitus:a retrospective cohort study in China[J].BMC Public Health,2012,12:567.
[12]Gallagher EJ,LeRoith D.The proliferating role of insulin and insulin-like growth factors in cancer[J].Trends Endocrinol Metab,2010,21(10):610-618.
[13]Komura T,Sakai Y,Honda M,et al.CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes[J].Diabetes,2010,59(3):634-643.
[14]Lecube A,Pachón G,Petriz J,et al.Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement[J].PLoS One,2011,6(8):e23366.
[15]Sgambato A,Cittadini A.Inflammation and cancer:a multifaceted link[J].Eur Rev Med Pharmacol Sci,2010,14(4):263-268.
[16]Godsland IF.Insulin resistance and hyperinsulinaemia in the development and progression of cancer[J].2009,118(5):315-332.
[17]Plate KH,Scholz A,Dumont DJ.Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited[J].Acta Neuropathol,2012,124(6):763-775.
[18]Kusumanto YH,Meijer C,Dam W,et al.Circulating vascular endothelial growth factor (VEGF) levels in advanced stage cancer patients compared to normal controls and diabetes mellitus patients with critical ischemia[J].Drug Target Insights,2007,2:105-109.
[19]Rolo AP,Palmeira CM.Diabetes and mitochondrial function:role of hyperglycemia and oxidative stress[J].Toxicol Appl Pharmacol,2006,212(2):167-178.
[20]Li ZY,Yang Y,Ming M,et al.Mitochondrial ROS generation for regulation of autophagic pathways in cancer[J].Biochem Biophys Res Commun,2011,414(1):5-8.
[21]Rojas A,González I,Morales E,et al.Diabetes and cancer:Looking at the multiligand/RAGE axis[J].World J Diabetes,2011,2(7):108-113.
[22]Bosetti C,Franchi M,Nicotra F,et al.Insulin and other antidiabetic drugs and hepatocellular carcinoma risk:a nested case-control study based on Italian healthcare utilization databases[J].Pharmacoepidemiol Drug Saf,2015,24(7):771-778.
[23]Eikawa S,Nishida M,Mizukami S,et al.Immune-mediated antitumor effect by type 2 diabetes drug,metformin[J].Proc Natl Acad Sci U S A,2015,112(6):1809-1814.
[24]Zheng L,Yang W,Wu F,et al.Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma[J].Clin Cancer Res,2013,19(19):5372-5380.
[25]Bhalla K,Hwang BJ,Dewi RE,et al.Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis[J].Cancer Prev Res (Phila),2012,5(4):544-552.
[26]Miele L,Bosetti C,Turati F,et al.Diabetes and insulin therapy,but not metformin,are related to hepatocellular cancer risk[J].Gastroenterol Res Pract,2015,2015:570356.
[27]Singh S,Singh PP,Singh AG,et al.Anti-diabetic medications and the risk of hepatocellular cancer:a systematic review and meta-analysis[J].Am J Gastroenterol,2013,108(6):881-891.
[28]Seo YS,Kim YJ,Kim MS,et al.Association of metformin use with cancer-specific mortality in hepatocellular carcinoma after curative resection:a nationwide population-based study[J].Medicine (Baltimore),2016,95(17):e3527.
[29]Bhat M,Chaiteerakij R,Harmsen WS,et al.Metformin does not improve survival in patients with hepatocellular carcinoma[J].World J Gastroenterol,2014,20(42):15750-15755.
[30]Yang X,Wang Y,Luk AO,et al.Enhancers and attenuators of risk associations of chronic hepatitis B virus infection with hepatocellular carcinoma in type 2 diabetes[J].Endocr Relat Cancer,2013,20(2):161-171.
[31]Monami M,Lamanna C,Balzi D,et al.Sulphonylureas and cancer:a case-control study[J].Acta Diabetol,2009,46(4):279-284.
[32]Currie CJ,Poole CD,Gale EA.The influence of glucose-lowering therapies on cancer risk in type 2 diabetes[J].Diabetologia,2009,52(9):1766-1777.
[33]Tsilidis KK,Capothanassi D,Allen NE,et al.Metformin does not affect cancer risk:a cohort study in the U.K.Clinical Practice Research Datalink analyzed like an intention-to-treat trial[J].Diabetes Care,2014,37(9):2522-2532.
[34]Li XQ,Sun GP.Relationship between chemotherapy and blood glucose of patients with malignancy[J].Qingdao Med J,2014,46(3):194-195.
[35]Luo K.Effects of chemotherapy on glycated hemoglobin and fasting plasma glucose in patients with malignant tumor[J].Laboratory Medicine and Clinic,2014,12(8):1025-1027.
[36]Liu L.Study on chemotherapy-induced glucose metabolic disorders and function of βCell of islet in patients with malignant neoplasm[D].Hefei:Anhui Medical University,2012.
[37]Wang ZH,Cui H,Li XP,et al.Study on factors inducing diabetes mellitus after chemotherapy[J].Chin J Clin Obstetric and Gynecol,2004,5(6):416-419.
[38]Di Costanzo GG,Tortora R,Morisco F,et al.Impact of diabetes on outcomes of sorafenib therapy for hepatocellular carcinoma[J].Target Oncol,2016.
[39]Masood MA,Zafar W,Yusuf MA.Is diabetes mellitus a poor prognostic factor for hepatocellular carcinoma[J]? J Gastrointest Cancer,2014,45(4):448-451.
[40]Wang YY,Huang S,Zhong JH,et al.Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma after curative hepatectomy[J].PLoS One,2014,9(12):e113858.
[41]Raffetti E,Portolani N,Molfino S,et al.Role of aetiology,diabetes,tobacco smoking and hypertension in hepatocellular carcinoma survival[J].Dig Liver Dis,2015,47(11):950-956.
[42]Wang YG,Wang P,Wang B,et al.Diabetes mellitus and poorer prognosis in hepatocellular carcinoma:a systematic review and Meta-analysis[J].PLoS One,2014,9(5):e95485.
[43]Zhang RL,Zhou SS,Xiao L,et al.Comparison of clinical characteristics of non-B non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma and prognosis in Uighur patients[J].Chin J Oncol,2015,37(7):540-544.
[44]Gao C,Zhao HC,Li JT,et al.Diabetes mellitus and hepatocellular carcinoma:comparison of Chinese patients with and without HBV-related cirrhosis[J].World J Gastroenterol,2010,16(35):4467-4475.
[45]Nkontchou G,Cosson E,Aout M,et al.Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients[J].J Clin Endocrinol Metab,2011,96(8):2601-2608.
[46]Kawamura Y,Ikeda K,Arase Y,et al.Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis[J].J Gastroenterol Hepatol,2008,23(11):1739-1746.
[47]Wang WM,Xu Y,Yang XR,et al.Prognostic role of diabetes mellitus in hepatocellular carcinoma patients after curative treatments:a Meta-analysis[J].Hepatobiliary Pancreat Dis Int,2011,10(4):346-355.
[48]Liu XH.Studies of diabetes mellitus and hepatocellular carcinoma[D].Guangzhou:Southern Medical University,2014.

Memo

Memo:
江苏省六大人才高峰(编号:2014-SWYY-026)
Last Update: 2017-01-26