|Table of Contents|

Research progress of ovarian cancer gene 1 in human malignant tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
823-827
Research Field:
Publishing date:

Info

Title:
Research progress of ovarian cancer gene 1 in human malignant tumor
Author(s):
Wang DexuYu Jingcui
Scientific Research Center,The Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
OVCA1tumor suppressor genecell cycleepigenetics
PACS:
R737.31
DOI:
10.3969/j.issn.1672-4992.2017.05.041
Abstract:
Ovarian cancer gene 1(OVCA1) is located on the 17p13.3 of human chromosome,and it is highly conserved in mammals.At the same time,the gene has the identity and similarity with the yeast DPH2.OVCA1 plays an important role in maintaining the fidelity of translation,regulating cell cycle and regulating embryonic development and so on.As a novel candidate tumor suppressor gene,there is a high frequency of LOH(loss of heterozygosity) and mutation of OVCA1 in a variety of tumors such as ovarian,breastand cervical cancers.Therefore the gene might play an important role in tumorigenesis and development of tumors.In this review,we would focus on the biological function of OVCA1 and its association with tumors.

References:

[1]Schultz DC.Identification of two candidate tumor suppressor genes on chromosome 17p13.3[J].Cancer Res,1996,56(9):1997-2002.
[2]Phillips NJ,Zeigler MR,Deaven LL.A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3[J].Cancer Lett,1996,102(1-2):85-90.
[3]Phillips NJ.Allelic deletion on chromosome 17p13.3 in early ovarian cancer[J].Cancer Res,1996,56(3):606-611.
[4]Emi M.Allelic loss at 1p34,13q12,17p13.3,and 17q21.1 correlates with poor postoperative prognosis in breast cancer[J].Genes Chromosomes Cancer,1999,26(2):134-141.
[5]Voeghtly LM.Molecular alterations associated with breast cancer mortality[J].PLoS One,2012,7(10):e46814.
[6]Kersemaekers AM.Loss of heterozygosity for defined regions on chromosomes 3,11 and 17 in carcinomas of the uterine cervix[J].Br J Cancer,1998,77(2):192-200.
[7]Tong R,Yang Q,Wang CY,et al.The significance of OVCA1 expression in cervical lesions and correlation with CyclinD1 and p16[J].Modern Oncology,2016,24(8):1264-1268.[佟锐,杨清,王纯雁,等.OVCA1在宫颈病变中表达的意义及与CyclinD1、p16的相关性[J].现代肿瘤医学,2016,24(8):1264-1268.]
[8]Sankar M.Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality[J].Leukemia,1998,12(4):510-516.
[9]Ninomiya S.Integrated analysis of gene copy number,copy neutral LOH,and microRNA profiles in adult acute lymphoblastic leukemia[J].Cytogenet Genome Res,2012,136(4):246-255.
[10]Tsuchiya E.Three new regions on chromosome 17p13.3 distal to p53 with possible tumor suppressor gene involvement in lung cancer[J].Jpn J Cancer Res,2000,91(6):589-596.
[11]Shikeeva AA.Allelic imbalance in patients with non-small cell lung cancer[J].Arkh Patol,2013,75(2):3-8.
[12]Chattopadhyay P.Loss of heterozygosity of a locus on 17p13.3,independent of p53,is associated with higher grades of astrocytic tumours[J].Oncogene,1997,15(7):871-874.
[13]Sarkar C.Role of 17p13.3 chromosomal region in determining p53 protein immunopositivity in human astrocytic tumors[J].Pathology,2000,32(2):84-88.
[14]Bruening W.Expression of OVCA1,a candidate tumor suppressor,is reduced in tumors and inhibits growth of ovarian cancer cells[J].Cancer Res,1999,59(19):4973-4983.
[15]Chen CM,Behringer RR.Cloning,structure,and expression of the mouse OVCA1 gene[J].Biochem Biophys Res Commun,2001,286(5):1019-1026.
[16]Liang M.OVCA1,a candidate gene of the genetic modifier of Tp53,Mop2,affects mouse embryonic lethality[J].Genes Chromosomes Cancer,2008,47(4):315-325.
[17]Liu S.Identification of the proteins required for biosynthesis of diphthamide,the target of bacterial ADP-ribosylating toxins on translation elongation factor 2[J].Mol Cell Biol,2004,24(21):9487-9497.
[18]Webb TR.Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development[J].J Cell Sci,2008,121(Pt 19):3140-3145.
[19]Roy V,Ghani K,Caruso M.A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin[J].PLoS One,2010,5(12):e15753.
[20]Abdel-Fattah W.Insights into diphthamide,key diphtheria toxin effector[J].Toxins (Basel),2013,5(5):958-968.
[21]Nobukuni Y,Kohno K,Miyagawa K.Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2[J].J Biol Chem,2005,280(11):10572-10577.
[22]Liu S.Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development[J].Proc Natl Acad Sci USA,2012,109(34):13817-13822.
[23]Stahl S.Loss of diphthamide pre-activates NF-kappaB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor[J].Proc Natl Acad Sci USA,2015,112(34):10732-10737.
[24]Ortiz PA.Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance[J].J Biol Chem,2006,281(43):32639-43268.
[25]Su X,Lin Z,Lin H.The biosynthesis and biological function of diphthamide[J].Crit Rev Biochem Mol Biol,2013,48(6):515-521.
[26]Arguelles S.Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets,XIAP and FGF2,under oxidative stress conditions[J].Free Radic Biol Med,2014,67:131-138.
[27]Mateyak MK,Kinzy TG.ADP-ribosylation of translation elongation factor 2 by diphtheria toxin in yeast inhibits translation and cell separation[J].J Biol Chem,2013,288(34):24647-24655.
[28]Liu S,Leppla SH.Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide,the target of bacterial ADP-ribosylating toxins[J].Mol Cell,2003,12(3):603-613.
[29]Tashiro E,Tsuchiya A,Imoto M.Functions of CyclinD1 as an oncogene and regulation of CyclinD1 expression[J].Cancer Sci,2007,98(5):629-635.
[30]Kong F.OVCA1 inhibits the proliferation of epithelial ovarian cancer cells by decreasing CyclinD1 and increasing p16[J].Mol Cell Biochem,2011,354(1-2):199-205.
[31]Chen CM,Behringer RR.OVCA1 regulates cell proliferation,embryonic development,and tumorigenesis[J].Genes Dev,2004,18(3):320-32.
[32]Chen CM,Behringer RR.OVCA1:tumor suppressor gene[J].Curr Opin Genet Dev,2005,15(1):49-54.
[33]Merlo A.5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers[J].Nat Med,1995,1(7):686-692.
[34]Pieretti M.Hypermethylation at a chromosome 17 "hot spot" is a common event in ovarian cancer[J].Hum Pathol,1995,26(4):398-401.
[35]Wales MM.p53 activates expression of HIC-1,a new candidate tumour suppressor gene on 17p13.3[J].Nat Med,1995,1(6):570-577.
[36]Stone RM.How I treat patients with myelodysplastic syndromes[J].Blood,2009,113(25):6296-6303.
[37]Hu X.Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8[J].Leuk Res,2013,37(11):1551-1556.
[38]Wang WY,Cheng WD,Li YH.Expression and significance of the hypermethylated in cancer 1 and ovarian cancer gene 1 in ovarian cancer[J].China Medical Engineering,2016,4:46-48.[王伟源,程文德,李彦华.癌超甲基化基因1与卵巢癌基因1在卵巢癌组织中的表达及意义[J].中国医学工程,2016,4:46-48.]
[39]Cornelis RS.Evidence for a gene on 17p13.3,distal to TP53,as a target for allele loss in breast tumors without p53 mutations[J].Cancer Res,1994,54(15):4200-4206.
[40]Phelan CM.Consortium study on 1280 breast carcinomas:allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters[J].Cancer Res,1998,58(5):1004-1012.
[41]Saxena A.Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from p53 in malignant astrocytomas[J].Cancer Res,1992,52(23):6716-6721.
[42]Steichen-Gersdorf E.Deletion mapping on chromosome 17p in medulloblastoma[J].Br J Cancer,1997,76(10):1284-1287.
[43]Yu JC.Human gastric adenocarcinoma allelotype on chromosomes 17 and 18[J].J Int Med Res,2008,36(2):279-288.
[44]Yu J.Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions[J].Mol Cells,2011,32(1):47-55.

Memo

Memo:
国家自然科学基金资助项目(编号:81372174);黑龙江省自然科学基金重点项目(编号:ZD201320)
Last Update: 2017-01-26