[1]Van Meer G.The different hues of lipid rafts[J].Science,2002,296(5569):855-857.
[2]Simons K,Toomre D.Lipid rafts and signal transduction[J].Nat Rev Mol Cell Biol,2000,1(1):31-39.
[3]Zajchowski LD,Robbins SM.Lipid rafts and little cavescompartmentalized signalling in membrane microdomains[J].Eur J Biochem,2002,269:737-752.
[4]Langhorst MF,Reuter A,Jaeger FA,et al.Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2[J].Eur J Cell Biol,2008,87(4):211-226.
[5]Bickel PE,Scherer PE,Schnitzer JE,et al.Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins[J].J Biol Chem,1997,272(21):13793-13802.
[6]Neumann-Giesen C,Fernow I,Amaddii M,et al.Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton[J].J Cell Sci 2007,120(3):395-406.
[7]Stuermer CA,Langhorst MF,Wiechers MF,et al.PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction[J].FASEB J,2004,18(14):1731-1733.
[8]Munro S.Lipid rafts elusive or illusive[J]? Cell,2003,115(3):377-388.
[9]Hazarika P,Dham N,Patel P,et al.Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation[J].J Cell Biochem,1999,75(1):147-159.
[10]Langhorst MF,Solis GP,Hannbeck S,et al.Linking membrane microdomains to the cytoskeleton:regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin[J].FEBS Lett,2007,581(24):4697-4703.
[11]Zhao L,Lin L,Pan C,et al.Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β[J].Oncotarget,2015,6(12):9781-9793.
[12]Zhang LH.A preliminary study of the expression and mechanism of Flotillin-2 in nasopharyngeal carcinoma[D].Changsha:Central South University,2012.[张立华.Flotillin-2在鼻咽癌中的表达及作用机制的初步探索[D].长沙:中南大学,2012.]
[13]Liu J,Huang W,Ren CP,et al.Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-kappaB and PI3K/Akt3 signaling pathways[J].Sci Rep,2015,5:11614.
[14]Berger T,Ueda T,Arpaia E,et al.Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model[J].Oncogene,2013,32(41):4989-4994.
[15]Xie G,Li J,Chen J,et al.Knockdown of Flot2 impairs the proliferation of breast cancer cells through modulation of Akt/FOXO signaling[J].Oncol Rep,2015,33(5):2285-2290.
[16]Wang YL,Yao WJ,Guo L,et al.Expression of flotillin-2 in human non-small cell lung cancer and its correlation with tumor progression and patient survival[J].Int J Clin Exp Pathol,2015,8(1):601-607.
[17]Mou X,Liu S.miR-485 inhibits metastasis and EMT of lung adenocarcinoma by targeting Flot2[J].Biochem Biophys Res Commun,2016,477(4):521-526.
[18]Cao K,Xie D,Cao P,et al.SiRNA-mediated flotillin-2 (Flot2) downregulation inhibits cell proliferation,migration,and invasion in gastric carcinoma cells[J].Oncol Res,2014,21(5):271-279.
[19]Li Q,Peng J,Li X,et al.miR-449a targets Flot2 and inhibits gastric cancer invasion by inhibiting TGF-β-mediated EMT[J].Diagn Pathol,2015,10:202.
[20]Yan Y,Yang FQ,Zhang HM,et al.Up-regulation of Flot2 is associated with renal cell carcinoma progression[J].Tumour Biol,2014,35(10):10479-10486.
[21]Xu Hongli,Hu Ping,Zhang Zhen,et al.Effect of silence of FLOT2 expression by siRNA on proliferation of human renal cell carcinoma cells[J].Modern Oncology,2015,23(23):3376-3379.[许洪礼,胡萍,张振,等.siRNA干扰FLOT2基因表达对肾细胞癌细胞增殖的影响[J].现代肿瘤医学,2015,23(23):3376-3379.]
[22]Liu YQ,Lin Li,Huang ZJ,et al.High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma[J].Int J Clin Exp Pathol,2015,8(1):622-628.
[23]Hazarika P,McCarty MF,Prieto VG,et al.Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1[J].Cancer Res,2004,64(20):7361-7369.
[24]Liu R,Xie H,Luo C,et al.Identification of FLOT2 as a novel target for microRNA-34a in melanoma[J].J Cancer Res Clin Oncol,2015,141(6):993-1006.
[25]Sasaki Y,Oshima Y,Koyama R,et al.Identification of flotillin-2,a major protein on lipid rafts,as a novel target of p53 family members[J].Mol Cancer Res,2008,6(3):395-406.