|Table of Contents|

Research progress of mechanism of bone invasion/metastasis in human neuroblastoma regulated by RANK/RANKL/OPG signaling pathway

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
813-816
Research Field:
Publishing date:

Info

Title:
Research progress of mechanism of bone invasion/metastasis in human neuroblastoma regulated by RANK/RANKL/OPG signaling pathway
Author(s):
Wang GuowenZhao Hongyu
Department of Neurosurgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
neuroblastomaRANK/RANKL/OPG pathwaybone invasion/metastasis
PACS:
R730.261
DOI:
10.3969/j.issn.1672-4992.2017.05.038
Abstract:
Neuroblastoma(NB) is the second solid tumor in children.Approximately 70 % of NB patients present metastatic dissemination at diagnosis.It is bone invasion and metastasis which is a crucial factor of morbidity and mortality in NB patients.In the process,a series of related factors were secreted by a mount of cells,such as neuroblastoma cells,osteoblasts and its precursor cells,osteoclasts and its precursor cells and bone marrow stromal cells to promote bone invasion/metastasis.In this paper,the progress of mechanism in bone invasion and metastasis of human NB cells regulated by RANK/RANKL/OPG pathway is reviewed.

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Memo

Memo:
国家自然科学基金资助面上项目(编号:81172410);辽宁省课题(编号:CB61,MCB61)
Last Update: 2017-01-26