|Table of Contents|

Pathological features of endometrial stromal sarcoma and poorly-differentiated endometrial adenocarcinoma and differential diagnosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
782-784
Research Field:
Publishing date:

Info

Title:
Pathological features of endometrial stromal sarcoma and poorly-differentiated endometrial adenocarcinoma and differential diagnosis
Author(s):
La Hui; Wei Zhenzhi; Qu Lixia; Quan Lili
Department of Gynaecology，Sanmenxia City Central Hospital,Henan Sanmenxia 472000，China.
Keywords:
endometrial stromal sarcoma; poorly-differentiated endometrial adenocarcinoma; clinical diagnosis; differential diagnosis
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2017.05.029
Abstract:
Objective：To investigate the endometrial stromal sarcoma and poorly-differentiated endometrial adenocarcinoma clinical and pathological features and differential diagnosis，in order to improve accuracy.Methods：A retrospective analysis in January 2010 to January 2013,12 endometrial stromal sarcoma and 12 cases of poorly-differentiated endometrial adenocarcinoma patients were summarized from grossly，microscopy，immunohistochemistry.Results：Endometrial stromal sarcoma tumor section most gray，pale yellow，no significant bleeding and necrosis.Poorly-differentiated endometrial adenocarcinoma showed slice surface intimal thickening，rough，brittle，uneven surface，uterine section some visible muscle invasive.Under microscopy endometrial stromal sarcoma showed tongue irregular island myometrial invasion，there broking into lymphatic vascular growth within the tumor cell density.It founded that relatively thin-walled spiral visible small blood vessels around the tumor blood vessels within the tumor cells arranged like concentric circles，the lack of endometrial stromal cell differentiation characteristics and typical growth pattern，no spiral of small blood vessels，associated with pelvic lymph node metastases.Poorly-differentiated endometrial adenocarcinoma showed more glandular glands，a few fine papillary，size and arrangement of extremely inconsistent to disappear，densely crowded glands，epithelial cell proliferation disorder，enlarged nuclei，nuclear cytoplasm ratio imbalance，infiltrate fibrous tissue surrounding obvious reaction.Endometrial stromal sarcoma ER positive rate was 25%，PR positive rate was 8.33%，while the poorly-differentiated endometrial adenocarcinoma ER-positive rate was 100%，PR positive rate of 100%，the difference was significant (P<0.05).Conclusion：Endometrial stromal sarcoma and poorly-differentiated endometrial adenocarcinoma is liable to differentiate on the examination and immunohistochemistry.

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三门峡市科技攻关基金项目(编号：2011030326)
Last Update: 2017-01-26