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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2017 05

Page:

779-782

Research Field:

Publishing date:

Info

Title:

Expression and clinical significance of PDCD4 and PDCD5 protein in 70 cases of ovarian cancer associated with endometriosis

Author(s):

Lin Shanqun¹; Gao Shuping²; Lu Yunping³; Yang Weidong⁴

1.Department of Gynecology；2.Department of Clinical Laboratory，Yangchun People's Hospital，Guangdong Yangchun 529600，China；3.Department of Gynecology and Obstetrics；4.Department of Clinical Laboratory，the Fifth People's Hospital of Dongguan City，Guangdong Dongguan，523900，China.

Keywords:

PDCD4; PDCD5; ovarian cancer; endometriosis

PACS:

R737.31

DOI:

10.3969/j.issn.1672-4992.2017.05.028

Abstract:

Objective：To study the expression level of PDCD4 and PDCD5 protein in patients with ovarian cancer (EAOC) and its clinical significance.Methods：The data of 70 cases of endometriosis associated ovarian cancer (EAOC) patients from February 2010 to February 2015 deleted into the observation group and 70 cases of simple ovarian cancer patients from the same time period to our hospital were delected into control group.Application of immune group method (Fnvisinn) was used for the detection of two groups of ovarian cancer patients with ovarian tissue programmed death 4 (PDCD4) gene and procedural death gene 5 (PDCD5) protein expression level，and two groups of data display results were compared and analyzed.Results：The PDCD4 protein positive rate of the observation group was 20.0%，and the control group patients with positive rate was 31.4%，PDCD4 protein positive rate of the observation group was significantly lower than that in the control group，the differences between the two groups of data significantly (P<0.05).PDCD5 protein positive rate of the observation group was 21.4%，and positive rate of the control group was 34.3%，the PDCD5 protein positive rate of the observation group was significantly lower than that of the control group，the differences between the two groups of data significantly (P<0.05).The contents of PDCD4 (0.39±0.11) and PDCD5 protein (0.41±0.12) in the observation group were significantly lower than those in the control group，and the data of the two groups were significantly different (P<0.05).Conclusion：Through the detection of endometriosis associated ovarian cancer patients of PDCD4，PDCD5 protein expression levels and can effectively diagnose the extent of the deterioration of the patient's condition，understanding the development of the disease，the clear condition type，contribute to the control and treatment of patients.It is worthy of popularization and application.

References:

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Memo

Memo:

阳江市医疗卫生类科技计划项目［编号：社发（2015）33］

Common functions

Last Update: 2017-01-26