|Table of Contents|

The prognostic value of Ki-67，p16 and CK34βE12 protein in surgical cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
785-790
Research Field:
Publishing date:

Info

Title:
The prognostic value of Ki-67，p16 and CK34βE12 protein in surgical cervical cancer
Author(s):
Gulixian·Tuluwengjiang; Zhang Song'an; Huerxidan·Niyazi; Zhang Lei; Reheman·Yiming; Bao Yongxing
Cancer Center，The First Affiliated Hospital of Xinjiang Medical University，Xinjiang Urumqi 830054，China.
Keywords:
Ki-67; p16; CK34βE12; cervical carcinoma; prognosis
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2017.05.030
Abstract:
Objective：To discuss the prognostic value of Ki-67，p16，CK34βE12 antigen，pathological features and postoperative adjuvant treatment on the operable cervical cancer patients.Methods：The expression of Ki-67，p16，CK34βE12 in 72 cases of postoperative cervical carcinoma was detected by immunohistochemistry to follow up the PFS，combining with pathological features and treatment of patients，ending with the progression of disease.Univariate factors were analyzed by Kaplan-Meier method，Multiple factors were analyzed by Cox regression analysis.Results：Univariate analysis showed that Ki-67(P=0.006)，CK34βE12(P=0.007)，the production situation(P=0.018)，menopausal status(P=0.008)，nationality(P=0.034)，pain situation(P=0.008)，tumor FIGO stage(P=0.000)，tumor size(P=0.015)，lymph node metastasis(P=0.000) and chemotherapy(P=0.016) related to the patients prognosis.Cox multivariate analysis showed the expression of Ki-67，age，maternity，menopausal status，degree of differentiation,depth of myometrial invasion,violations along the uterus，radiotherapy can effect the PFS(P<0.05).However，the expression of p16 and CK34βE12 patient antigen，tumor size，differenrtiated degree，age at menarche，nationality，occupation，surgery and chemotherapy had no significant effect on PFS(P>0.05)，not yet as independent prognostic factors.Conclusion：Ki-67 high expression，young，premature delivery，late tumor stage，deep grass roots and violations along the uterus，and the radiotherapy are the independent prognostic factors of cervical cancer.Expression of p16 and CK34βE12 antigens，tumor size，degree of differentiation，age at menarche，nationality，occupation，surgery and chemotherapy are related to the prognosis only，not yet as an independent prognostic factor.

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新疆研究生科研创新项目(编号：XJGRI2015065）
Last Update: 2017-01-26