|Table of Contents|

The relationship between gene polymorphism of XRCC3 Thr241Met and gastric cancer susceptibility：A Meta-analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
744-749
Research Field:
Publishing date:

Info

Title:
The relationship between gene polymorphism of XRCC3 Thr241Met and gastric cancer susceptibility：A Meta-analysis
Author(s):
Zhang Baoying; Cui Jing; Jiang Lei; Guan Quanlin
Department of Oncological Surgery，The First Hospital of Lanzhou University，Gansu Lanzhou 730000，China.
Keywords:
stomach neoplasms; XRCC3; polymorphism; SNP; Meta-analysis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2017.05.019
Abstract:
Objective：To evaluate the relationship between Thr241Met polymorphism of X-ray repair cross-complementing group 3 (XRCC3) gene and gastric cancer susceptibility.Methods：The relevant published studies were retrieved from China National Knowledge Infrastructure，Chinese Biomedical Literature Database，Chinese Science and Technology Periodicals Data，Wan Fang databases，PubMed and Cochrane Library with computer.The statistical analysis was conducted by the Stata 12.0 software.Odd ratio (OR) and 95％confidence interval (CI) for XRCC3 Thr241Met polymorphism and gastric cancer were calculated.Results：The Meta-analysis included 12 case-control studies.Although our Meta-analysis indicated null association of XRCC3 gene rs861539 polymorphism between gastric cancer patients and controls under gross effect，the source of controls and whether conform to Hardy-Weinberg equilibrium.Stratified analysis by ethnicity demonstrated a significant association in Asians under recessive model （MM vs MT+TT：OR=2.59，95%CI：1.98~3.39，P<0.001），allelic model （M vs T：OR=1.57，95%CI：1.05~2.35，P=0.028） and homozygous model （MM vs TT：OR=3.39，95%CI：2.17~5.31，P<0.001).Conclusion：The XRCC3 gene Thr241Met polymorphism was associated with the risk for gastric cancer in Asian populations.

References:

［1］Ferlay J，Soerjomataram I，Dikshit R，et al.Cancer incidence and mortality worldwide：sources，methods and major patterns in GLOBOCAN 2012［J］.International J Cancer，2015，136(5)：E359-E386.
［2］Rosati G，Ferrara D，Manzione L.New perspectives in the treatment of advanced or metastatic gastric cancer［J］.World J Gastroenterology，2009，15(22)：2689-2692.
［3］Qin XP，Zhou Y，Chen Y，et al.XRCC3 Thr241Met polymorphism and gastric cancer susceptibility：A Meta-analysis［J］.Clinics and Research in Hepatology and Gastroenterology，2014，38(2)：226-234.
［4］Goode EL，Ulrich CM，Potter JD.Polymorphisms in DNA repair genes and associations with cancer risk［J］.Cancer Epidemiology，Biomarkers & Prevention，2002，11(12)：1513-1530.
［5］He XF，Wei W，Li JL，et al.Association between the XRCC3 T241M polymorphism and risk of cancer：evidence from 157 case-control studies［J］.Gene,2013，523(1)：10-19.
［6］Fang F，Wang J，Yao L，et al.Relationship between XRCC3 T241M polymorphism and gastric cancer risk：A Meta-analysis［J］.Medical Oncology (Northwood，London，England),2011，28(4)：999-1003.
［7］Mohrenweiser HW，Jones IM.Variation in DNA repair is a factor in cancer susceptibility：a paradigm for the promises and perils of individual and population risk estimation［J］? Mutation Research，1998，400(1-2)：15-24.
［8］Luo HC，Zhang HB，Xin XJ，et al.Haplotype-based case-control study of DNA repair gene XRCC3 and hepatocellular carcinoma risk in a Chinese population［J］.Tumour Biology，2014，35(4)：3415-3419.
［9］Zhu X，Zhong Z，Zhang X，et al.DNA repair gene XRCC3 T241M polymorphism and bladder cancer risk in a Chinese population［J］.Genetic Testing and Molecular Biomarkers，2012，16(6)：640-643.
［10］Gresner P，Gromadzinska J，Polanska K，et al.Genetic variability of XRCC3 and RAD51 modulates the risk of head and neck cancer［J］.Gene，2012，504(2)：166-174.
［11］Shen H，Wang X，Hu Z，et al.Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population［J］.Cancer Letters，2004，206(1)：51-58.
［12］Duarte MC.Polymorphisms of DNA repair genes XRCC1 and XRCC3，interaction with environmental exposure and risk of chronic gastritis and gastric cancer［J］.World J Gastroenrology (Electronic Edition)，2005，11(42)：6593-6600.
［13］Huang WY，Chow WH，Rothman N，et al.Selected DNA repair polymorphisms and gastric cancer in Poland［J］.Carcinogenesis,2005，26(8)：1354-1359.
［14］Huang GP，Zheng ZL，Cai L.DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to cardia and non-cardia gastric cancer：a case-control study［J］.Chin J Epidemiology，2006，27(5)：420-423.
［15］Ye W，Kumar R，Bacova G，et al.The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma：a population-based case-control study in Sweden［J］.Carcinogenesis，2006，27(9)：1835-1841.
［16］Ruzzo A，Canestrari E，Maltese P，et al.Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer［J］.Clinical Chemistry and Laboratory Medicine：CCLM/ESCC，2007，45(7)：822-828.
［17］Palli D，Polidoro S，D'Errico M，et al.Polymorphic DNA repair and metabolic genes：a multigenic study on gastric cancer［J］.Mutagenesis,2010，25(6)：569-575.
［18］Canbay E，Agachan B，Gulluoglu M，et al.Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer［J］.Anticancer Research，2010，30(4)：1359-1364.
［19］Zhao L，Long XD，Yao JG，et al.Genetic polymorphism of XRCC3 codon 241 and Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi Population，China：A hospital-based case-control study［J］.Cancer epidemiology，2011，35(6)：564-568.
［20］Cheng S，Wang L，Wang L，et al.Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk：evidence from a case-control study and a meta-analysis［J］.International J Clinical and Experimental Pathology，2015，8(2)：1911-1919.
［21］Gok I，Baday M，Cetinkunar S，et al.Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey［J］.Bosnian J Basic Medical Sciences，2014，14(4)：214-218.
［22］Bashir H，Majid S，Hamid R，et al.Polymorphism of the XRCC3 gene and risk of gastric cancer in a Kashmiri population：a case-control study［J］.European J Cancer Prevention (ECP)，2015，24(3)：167-175.
［23］Wen S，Liu TQ，Liu FF，et al.The significance of DNA repair protein expression in the process of gastric cance［J］.J Dalian Medical University，2010，32(06)：648-651.［温爽，刘天卿，刘飞飞，等.胃癌发生过程中DNA修复蛋白表达的意义［J］.大连医科大学学报，2010，32(06)：648-651.］
［24］Shen MR，Jones IM，Mohrenweiser H.Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans［J］.Cancer Research，1998，58(4)：604-608.
［25］Yu K，Zhang J，Zhang J，et al.Methionine synthase A2756G polymorphism and cancer risk：A Meta-analysis［J］.European J Human Genetics：EJHG，2010，18(3)：370-378.

Memo

Memo:
甘肃省科技支撑计划项目（编号：1504FKCA084）；甘肃省卫生行业科研计划项目（编号：GSWST2013-16）
Last Update: 2017-01-26