|Table of Contents|

Study on the relationship between PTHrP expression and cancer cell senescence in mice with Lewis lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
705-708
Research Field:
Publishing date:

Info

Title:
Study on the relationship between PTHrP expression and cancer cell senescence in mice with Lewis lung cancer
Author(s):
Liu WenwenFang Ningyuan
Department of Geriatrics,Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200127,China.
Keywords:
lung cancerparathyroid hormone related proteinsingle carboxylic acid transporter 1cell senescence
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.05.008
Abstract:
Objective:To establish Lewis lung cancer bearing mice animal model,and study the correlation between MCT1 and PTHrP expression in lung cancer cells and the relationship with cancer cell senescence.Methods:A total of 30 C57BL/6 mice were randomly divided into three groups:normal mice group (first groups),early cancer group (second group),and advanced cancer group (third groups).The expression of PTHrP and MCT1 was detected by immunohistochemistry.Results:The positive expression of three groups of animal cells PTHrP protein secretion and MCT1 rate highly consistent,and significantly negatively correlated with senescence associated markers of beta Gal expression,two indicators expression in group 3 than in group 2 and group 1 significantly(P<0.05).In group 2 expression than in group 1 expression was significantly increased(P<0.05).Conclusion:The expression of PTHrP and MCT1 in the advanced tumor tissues had significant positive correlation,and the expression of beta Gal was negatively correlated with the aging related indexes.

References:

[1]Zhu Chaonan,Wang Ping,Yang Hui,et al.Study on the expression of MCT1 and CD147 in non small cell lung cancer and its correlation[J].J Med University Of Anhui,2012,47(9):1086-1091[朱超男,王平,杨慧,等.MCT1、CD147在非小细胞肺癌中的表达及其相关性研究[J].安徽医科大学学报,2012,47(9):1086-1091.]
[2]Hastings RH,Burton DW,Nefzi A,et al.Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression[J].Cancer Biol Therapy,2010,10(10):1067-1075.
[3]Hastings RH,Montgrain PR,Quintana R,et al.Cell cycle actions of parathyroid hormone-related protein in non-small cell lung carcinoma[J].Am J Physiol,2009,297(4):L578-L585.
[4]Fleming N,Trivett MK,George J,et al.Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ[J].Cancer Res,2009,69(18):7473-7479.
[5]Liu Guipeng,Wang Shuang,Zhang Chunmei.The inhibitory effect of prolactin on cisplatin induced apoptosis in ovarian cancer[J].J China Med University,2013,42(5):447-450.[刘贵鹏,王爽,张春梅.催乳素对顺铂诱导卵巢癌细胞凋亡过程的抑制作用[J].中国医科大学学报,2013,42(5):447-450.]
[6]Lu Yufei,Sun Yanan,Zheng Xiaoli,et al.Efficacy analysis of neoadjuvant chemotherapy for esophageal squamous cell carcinoma[J].China J,2015,22(6):457-462.[陆寓非,孙亚楠,郑晓丽,等.食管鳞癌新辅助放化疗术后化疗疗效分析[J].中华肿瘤防治杂志,2015,22(6):457-462.]
[7]Yamada T,Muguruma H,Yano S,et al.Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice[J].Molecular Cancer Therapeutics,2009,8(1):119-126.
[8]Bhatia V,Saini MK,Falzon M.Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival[J].Regulatory Peptides,2009,158(1):149-155.
[9]Downs TM,Burton DW,Araiza FL,et al.PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3[J].Cancer Letters,2011,306(1):52-59.
[10]Mills TA,Orloff M,Domingo-Vidal M,et al.Parathyroid hormone-related peptide-linked hypercalcemia in a melanoma patient treated with ipilimumab:hormone source and clinical and metabolic correlates[J].Seminars Oncology,2015,42(6):909-914.
[11]Wang Xiaohu,Gao Yuanjun,Li Deping,et al.A meta-analysis of gastric adenocarcinoma of parathyroid hormone related protein expression and its clinical significance[J].Clinical,2012,27(3):217-218.[王小虎,郜元军,李德平,等.胃腺癌甲状旁腺激素相关蛋白的表达及临床意义[J].临床荟萃,2012,27(3):217-218.]
[12]Pinheiro C,Reis RM,Ricardo S,et al.Expression of monocarboxylate transporters 1,2,and 4 in human tumours and their association with CD147 and CD44[J].J Biomed Biotechnol,2010,2010:694.

Memo

Memo:
-
Last Update: 2017-01-26