|Table of Contents|

Inhibition of autophagy promote Bevacizumab-induced growth inhibition and apoptosis of colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 03
Page:
345-351
Research Field:
Publishing date:

Info

Title:
Inhibition of autophagy promote Bevacizumab-induced growth inhibition and apoptosis of colon cancer
Author(s):
Zhong LiZhao Zhi
Gastrointestinal Department,the Affiliated Hospital of Guilin Medical College,Guangxi Guilin 541000,China.
Keywords:
anti-VEGFBevacizumabautophagycolon cancer
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2017.03.003
Abstract:
Objective:To explore the relationship between anti-VEGF and autophagy.Methods:After HT-29 cells treated with Bevacizumab in the absence or presence of CQ,we explored apoptosis,proliferation and autophagy.Results:VEGF were upregulated in colorectal cancer.Moreover,patients with high VEGF expression showed significantly shorter overall survival.In addition,Bevacizumab inhibited the viability of human colon cancer cells in a dose-and time-dependent manner and induce apoptosis.At the last,treatment with Bevacizumab induced protective autophagy in colon cancer cells.Conclusion:Inhibition of autophagy promotes the effect of growth inhibition and apoptosis of colon cancer.

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Memo

Memo:
吴阶平医学基金项目(编号:320.6750.13390)
Last Update: 2016-12-29