|Table of Contents|

Effects and safety of compound Kushen injection combined with cisplatin on malignant pleural effusion

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
230-233
Research Field:
Publishing date:

Info

Title:
Effects and safety of compound Kushen injection combined with cisplatin on malignant pleural effusion
Author(s):
Liu Ling; Zhong Shishou; Li Guomiao
Department of Medical Oncology,the Second People's Hospital of Neijiang,Sichuan Neijiang 641000,China.
Keywords:
compound Kushen injection; cisplatin; lung cancer; malignant pleural effusion
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.02.018
Abstract:
Objective:To evaluate the efficacy and adverse reactions of compound Kushen injection combined with cisplatin for malignant pleural effusion caused by lung cancer compared with cisplatin regimen alone.Methods:With randomized and controlled method,the patients who were diagnosed as malignant pleural effusion were divided into treatment group and control group.Treatment group:Compound Kushen injection 20mg and cisplatin 40mg dissolved in saline 50ml injection into the chest,while the subsequent injection of dexamethasone 10mg once a week for 4 times.Control group:Cisplatin 40mg dissolved in saline 50ml injection into the chest,while the subsequent injection of dexamethasone 10mg once a week for 4 times.Results:The total effective rate was 80.00% in treatment group(complete remission in 13 cases and partial remission in 11 cases) and it was statistically different compared with control group that was 53.33%(complete remission in 7 cases and partial remission in 9 cases) (P＜0.05).Quality of life improvement rate of treatment group was higher than the control group(76.67% vs 50.00%,P＜0.05).The incidence of gastrointestinal reactions of treated patients was lower than the control group (16.67% vs 43.33%,P＜0.05).The incidence of neutrophils decrease of treatment group was lower than the control group (20.00% vs 46.67%,P＜0.05).Both groups showed no apparent function of liver and kidney damage and cardiac toxicity.Conclusion:Compound Kushen injection combined with cisplatin has good curative effects，low side effects,and patients can be tolerated.

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Last Update: 2016-12-01