|Table of Contents|

Expression and correlation of Livin and Bcl-2 proteins in primary lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
227-230
Research Field:
Publishing date:

Info

Title:
Expression and correlation of Livin and Bcl-2 proteins in primary lung cancer
Author(s):
Chai Chunyan1; Wang Ting1; Liu Bo2; Li Yali3
1.Department of Geriatrics；2.Department of Cardiology，Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;3.Department of Respiratory Medicine,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
lung neoplasms; Livin gene; Bcl-2 gene; immunohistochemistry
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.02.017
Abstract:
Objective:To study the expression of Livin and it's relationship with expression of Bcl-2 in primary lung cancer.Methods:The protein expression of Livin and Bcl-2 gene in paraffin specimens of lung cancer and specimens of normal lung tissues were detected by SP immunohistochemistry.Results:Livin and Bcl-2 protein expression showed high level in lung cancer specimens and were negative staining in the normal lung tissues.The positive rate of Livin protein expression in male lung cancer specimens(62.96%)was higher than that in female lung tissues(40.00%，P＜0.05).The positive rates of Livin and Bcl-2 protein expression in specimens with lymph node metastasis(78.95% and 68.42%)were higher than in tissues without lymph node metastasis(36.36% and 27.27%，P＜0.05).The protein expression of Bcl-2 gene in squamous cell carcinoma lung tissues(58.82%)was higher than that in adenocarcinoma lung tissues(20.45%).The positive rates of expressions of Livin and Bcl-2 protein were higher in patients smoking index ≥400 than patients with <400,the differences were significant(P＜0.05).Livin protein expression in lung cancer had no obvious relationship with the grade and clinical stage.Livin protein expression was positively related to Bcl-2 protein expression in primary lung cancer.Conclusion:Aberrant expression may be a new target for diagnosis and gene treatment of primary lung cancer.The aberrant expression of Livin and apoptosis related gene Bcl-2 may play synergetic roles in process of carcinogenesis of lung cancer.

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Last Update: 2016-12-01