«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2017 01

Page:

119-122

Research Field:

Publishing date:

Info

Title:

The expression and clinical significance of PCNA and pRb2/p130 in endometrial carcinoma

Author(s):

Liang Qiaoqing¹; Liang Keqing¹; Qin Rui²; Wen Wei¹; Mo Qiurong¹

1.Department of Pathology；2.Department of Gynecology，Guangxi Minzu Hospital，Guangxi Nanning 530001，China.

Keywords:

PCNA; pRb2/p130; endometrial carcinoma; immunohistochemical

PACS:

R737.33

DOI:

10.3969/j.issn.1672-4992.2017.01.032

Abstract:

Objective：To investigate the expressions of PCNA and pRb2/p130，their correlation and relationship with the pathological clinical features of normal endometrial tissue，endometrial hyperplasia，atypical endometrial hyperplasia and human endometrial carcinoma.Methods：Thirty normal endometrial tissue，30 endometrial hyperplasia，40 atypical endometrial hyperplasia and 76 endometrial carcinomas were collected.Immunohistochemistrical methods were used to detect pRb2/p130 and PCNA expressions.Results：In the atypical endometrial hyperplasia and endometrial carcinomas，the expressions of PCNA were significantly higher than that of normal and endometrial hyperplasia（P=0.043；P=0.020，respectively)，but the expression of pRb2/p130 was significantly lower than that of normal and endometrial hyperplasia.In the endometrial carcinomas，the expression of PCNA was significantly related tumor grade，staging，lymph node metastasis and ER respectively（P<0.05).The expressions of PCNA were significantly higher than that of endometrial hyperplasia（P=0.045).The expression of pRb2/p130 was significantly realted with age,histopathologic types，invasion depth，lymph node metastasis and ER respectively（P<0.05).There was negative correlation between the expressions of pRb2/p130 protein and that of PCNA（r=-0.331，P=0.003）.Conclusion：The abnormal expression of pRb2/p130，and PCNA in the atypical endometrial hyperplasia and that of endometrial carcinomas，combined together，could be considered new parameter to be evaluated in discriminating patients at higher risk for endometrial carcinoma.

References:

［1］Liu ZY，Yi J，Zou XM.Relationship between the expression of PCNA，E2F-1，RASSF1A and the biological behavior in human gastric carcinoma［J］.Heilongjiang Medicine and Pharmacy，2013，26（5）：768-771.［刘志勇，易坚，邹小明.PCNA、E2F-1、RASSF1A蛋白表达与胃癌生物学关系研究［J］.黑龙江医药科学，2013，26（5）：768-771.］
［2］Wan Yong，Wu XY.The expression and clinical significance of PCNA and EMMPRIN in esophagus seqence carrcinoma［J］.Chin J Current Advances in General，2011，31（2）：141-144.［万勇，吴心愿.PCNA和EMMPRIN在食管鳞癌中及其临床关系［J］.中国现代普通外科进展，2011，31（2）：141-144.］
［3］Sun J，Yang LC，Li SH，et al.Expression and relationship research of PCNA and p21 in endometrial carcinoma tissue［J］.J Taishan Med College，2014，11：1111-1113.［孙炯，杨留才，李仕红等.p21和PCNA在子宫内膜癌中表达水平及相关研究［J］.泰山医学院学报，2014，11：1111-1113.］
［4］Shang R，Tong LB.Expression of proliferating cell nuclear antigen，ER and PR in endometrial carrcinoma［J］.Heilongjiang Medicine and Pharmacy，2014，37(3)：56-57.［尚睿，佟丽波.PCNA、ER和PR在子宫内膜癌中表达［J］.黑龙江医药科学，2014，37（4）：56-57.］
［5］FIGO Committee on Gynecologic Oncology.FIGO staging for carcinoma of the vulva，cervix，and corpus uteri［J］.Int J Gynaecol Obstet，2014，125(2)：97-98.
［6］Weng SB，Zheng C，Zhang SY，et al.The expression and clinical significance of PCNA，VEGF and ER in thyroid papillary carcinoma［J］.Med Res Education，2010，27(1)：21-23.［瓮生彬，郑超，张淑艳，等.PCNA、VEGF、ER在甲状腺乳头状癌中的表达及临床意义［J］.医学研究与教育，2010，27(1)：21-23.］
［7］Lu ZZ，Yao XW，Chen SS，et al.The expression and significance of p53 and proliferating cell nuclear antigen in oral leukoplakla and oral squamous cell carcinoma［J］.Chin J Stomatol Res，2011，5(5)：16-19.［卢子正，姚小武，陈仕生，等.p53和增殖细胞核抗原在口腔白斑和口腔鳞状细胞癌中的表达和意义［J］.中华口腔医学研究杂志，2011，5(5)：16-19.］
［8］Wei RH，Wu LQ,Huang HY，et al.Expression and significance of proliferating cell nuclear antigen and COX-2 in endometrial carrcinoma［J］.Maternal and Child Health Care of China，2013，28（23）：3835-3837.［韦瑞红，伍丽群，黄海玉，等.PCNA和COX-2蛋白在子宫内膜癌中的表达及意义［J］.中国妇幼保健，2013，28（23）：3835-3837］.
［9］Sun YM，Wu M，Liu HX，et al.Expression of p53，p21 and PCNA and its correlation with recurrence in the negative surgical margin of early-stage laryngeal cancer［J］.Chin J Clin Oncol，2014，41(16)：1036-1040.［孙玉满，吴蒙，刘宏侠，等.喉癌切缘组织中p53、p21及PCNA表达及其肿瘤复发的关系［J］.中国肿瘤临床，2014，41（16）：1036-1040.］
［10］Yoshida M，Katsuda S，Maekawa A.Involements of estrogen receptor，proliferating cell nuclear antigen and p53 in endometrial carcinoma development in donryu rats［J］.J Toxicol Pathol，2012，25(2)：241-247.
［11］Merola E，Mattioli E，Minimo C，et al.Immunohistochemical evaluation of pRb2/p130，VEGF，EZH2，p53，p16INK4A，p21WAF1，p27KIP1 and PCNA in barrett's esophagus［J］.J Cell Physiol，2006，207(10)：512-519.
［12］Wei RH，Huang HY，Peng BL.Expression and significance of proliferating cell nuclear antigen and p21 in endometrial carrcinoma［J］.J Chin Diag Therapy，2012，26（6)：568-570.［韦瑞红，黄海玉，彭碧玲.PCNA和p21在子宫内膜癌中的表达及意义［J］.中华实用诊断与治疗杂志，2012，26（6）：568-570.］

Memo

Memo:

广西卫生厅科研立项课题（编号：Z2013282）

Common functions

Last Update: 2016-12-01