|Table of Contents|

Correlation between del(17p13) and LDH as well as the effects of del(17p13) on prognosis in myeloma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 01
Page:
115-119
Research Field:
Publishing date:

Info

Title:
Correlation between del(17p13) and LDH as well as the effects of del(17p13) on prognosis in myeloma
Author(s):
-
Department of Hematology,Zhongnan Hospital of Wuhan University,Hubei Wuhan 430071,China.
Keywords:
multiple myelomafluorescence in situ hybridisationdel(17p13)LDH
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2017.01.031
Abstract:
Objective:To analyze the correlation between del(17p13) (TP53) and clinical data,and the effects of del(17p13) on prognosis in myeloma.Methods:56 newly diagnosed multiple myeloama (MM) patients' clinical data were collected.All bone marrow samples were detected by FISH.The statistical analysis was performed using SPSS 19.0.Chi-square test was used to study the relation between del(17p13) and clinical basic data.t test was used to study the relation between del(17p13) and laboratory features.Kaplan-Meier was applied to analyze the survival duration.Results:Deletion of the TP53 gene (located at 17p13) was detected in 12 of 48 patients (21.43%).Del(17p13) was associated with LDH levels (P=0.034),but there was no correlation with patient gender,age,isotype,D-S stage,ISS stage,platelet,albumin,globulin,beta-2 microglobulin,BUN,creatinine,blood calcium,or bone marrow plasmacytosis.Patients with del(17p13) had significantly shorter PFS and OS(P<0.05).Conclusion:Del(17p13) affected partial biological behavior of MM cases,and was associated with poor prognosis.

References:

[1]Pavel Nemec,Zuzana Zemanova.Gain of 1q21 is an unfavorable genetic prognostic factor for multiple myeloma patients treated with high-dose chemotherapy[J].Biology of Blood and Marrow Transplantation,2010,16(4):548-554.
[2]Zhang ZN.Blood disease diagnosis and treatment standards[M].Beijing:Science Press,2007:232-235.[张之南.血液病诊断及疗效标准[M].北京:科学出版社,2007:232-235.]
[3]Deng SH.Features of extramedullary disease of multiple myeloma:high frequency of p53 deletion and poor survival:a retrospective single-center study of 834 cases[J].Clinical Lymphoma Myeloma and Leukemia,2015,15(5):286-291.
[4]Chng WJ,Price-Troska T,Gonzalez-Paz,et al.Clinical significance of TP53 mutation in myeloma[J].Leukemia,2007,21:582-584.
[5]Fonseca R,Barlogie B,Bataille R,et al.Genetics and cytogenetics of multiple myeloma:A workshop report[J].Cancer Res,2004,64:1546-1558.
[6]Segges P,Braggio E,Minnicelli C,et al.Genetic aberrations in multiple myeloma characterized by cIg-FISH:a Brazilian context[J].Brazilian J Medical and Biological Res,2016,49(5):e5034.
[7]Chim CS,Sim J,Tam S,et al.LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens[J].Eur J Haematol,2015,94(4):330-335.
[8]KD Boyd,FM Ross,WJ Tapper,et al.The clinical impact and molecular biology of del(17p) in multiple myeloma treated with conventional or thalidomide-based therapy[J].Genes Chromosomes and Cancer,2011,50:765-774.
[9]Moreau P,Cavo M,Sonneveld P,et al.The combination of ISS3,high LDH and t(4;14) and/or del(17p) identifies patients with multiple myeloma (MM) treated with front-lineautologous stem cell transplantation at high-risk of early MM progression-related death[J].J Clin Oncol,2014,132(20):2173-2180.
[10]Hebraud B,Magrangeas F,Cleynen A,et al.Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma:the IFM experience[J].Blood,2015,125(13):2095-2100.
[11]S Mangiacavalli,L Pochintesta,F Cocito,et al.Correlation between burden of 17p13.1 alteration and rapid escape toplasma cell leukaemia in multiple myeloma[J].British J Haematol,2013,162:555-558.
[12]Reece D,Song KW,Fu T,et al.Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone:Adverse effect of deletion 17p13[J].Blood,2009,114:522-525.
[13]Sonneveld P,Avet-Loiseau H,Lonial S,et al.Treatment of multiple myeloma with high-risk cytogenetics:a consensus of the international myeloma working group[J].Blood,2016,127(24):2955-2962.
[14]Leleu X,Karlin L,Macro M,et al.Pomalidomide plus low-dose dexamethasone in multiple myeloma with deletion 17p and/or translocation (4;14):IFM 2010-02 trial results[J].Blood,2015,25(9):1411-1417.
[15]Dimopoulos MA,Weisel KC,Song KW,et al.Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone[J].Haematologica,2015,100(10):1327-1333.
[16]Avet-Loiseau H,Leleu X,Roussel M,et al.Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p)[J].J Clin Oncol,2010,28(30):4630-4634.
[17]Bergsagel PL,Mateos MV,Gutierrez NC,et al.Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiplemyeloma[J].Blood,2013,121:884-892.
[18]PJ Teoh,WJ Chng.p53 abnormalities and potential therapeutic targeting in multiple myeloma[J].Bio Med Res International,2014,2014:717-919.

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国家自然科学基金面上项目(编号:81172257)
Last Update: 2016-12-01