|Table of Contents|

Association between EGF gene polymorphism and risk of renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
984-988
Research Field:
Publishing date:

Info

Title:
Association between EGF gene polymorphism and risk of renal cell carcinoma
Author(s):
CHENG Jiaying1; 2; ZHAO Lingyan1; 2; BAI Ruixia3; QIAO Jiankun4; LIU Junfeng4; YUE Genquan5; ZHOU Xuying1; 2; LIU Qi1; 2; GAO Yumin1; 2
1.School of Public Health；2.Laboratory of Molecular Epidemiology of Chronic Diseases,Inner Mongolia Medical University,Inner Mongolia Hohhot 010110,China;3.Department of Laboratory Medicine;4.Department of Urology,Inner Mongolia People's Hospital,Inner Mo
Keywords:
epidermal growth factor; renal cell carcinoma; polymorphism
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2021.06.016
Abstract:
Objective:To investigate the relationship between epidermal growth factor (EGF) polymorphism and environmental factors and the susceptibility to renal cell carcinoma (RCC).Methods:Using the case-control study method,a total of 67 patients with newly diagnosed RCC as case group were selected from the Affiliated Hospital of Inner Mongolia Medical University and Inner Mongolia People's Hospital.The control group included 67 healthy individuals who had undergone physical examinations at the same hospitals.The patients in the case group and the control group were investigated with a unified questionnaire.The genotype of EGF G61A was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),and the distribution frequency of genotype and allele was analyzed.Single factor and multiple factor Logistic regression analysis were used to analyze the relationship between EGF polymorphism and environmental factors and the susceptibility to RCC.Results:The distribution of genotype frequency and allele frequency in case group and control group had no statistical significance (P＞0.05).There was no significant difference in the risk of RCC between different genotypes (P＞0.05).Meat-based diet and animal oil consumption were risk factors for RCC,and education level was related to RCC.Conclusion:This study does not suggest that the G61A polymorphism of the EGF gene is associated with genetic predisposition in RCC.

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Memo

Memo:
内蒙古自治区卫生计生科研计划项目（编号：201701040）；内蒙古医科大学“三位一体”大学生创新创业培育项目（编号：SWYT2018009）
Last Update: 1900-01-01