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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2021 06

Page:

989-993

Research Field:

Publishing date:

Info

Title:

Diagnostic value of peripheral blood NLR combined with serum AFP,GP73 and DKK1 in primary hepatocellular carcinoma

Author(s):

LIANG Fang¹; ZHANG Hao²; GAO Hui¹; CHENG Duo¹; ZHANG Nan¹; DU Jie¹; ZHAO Beibei¹; DU Peng³

1.Cancer Rehabilitation Ward;2.Urology Department,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Henan Zhengzhou 450000,China;3.Urology Department,Peking University Cancer Hospital,Beijing 100000,China.

Keywords:

primary hepatocellular carcinoma; neutrophil to lymphocyte ratio; alpha fetoprotein; Golgi protein 73; Dickkopf-1; diagnosis

PACS:

R735.7

DOI:

10.3969/j.issn.1672-4992.2021.06.017

Abstract:

Objective:To investigate the diagnostic value of peripheral blood neutrophil to lymphocyte ratio (NLR) combined with serum alpha fetoprotein (AFP),Golgi protein 73 (GP73) and Dickkopf-1 (DKK1) levels in primary hepatocellular carcinoma (PHC).Methods:110 patients with PHC admitted to our hospital from June 2018 to June 2019 were selected as PHC group,90 patients with liver cirrhosis (LC) as LC group,90 patients with chronic hepatitis B (CHB) as CHB group,and 90 healthy people as control group.The number of neutrophils (Neu) and lymphocytes (Ly) was measured by automatic hematology analyzer (URIT-3060),and the NLR was calculated.The serum levels of AFP,GP73 and DKK1 were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The levels of NLR and serum AFP,GP73,DKK1 were compared among the four groups.The relationship between NLR and TNM staging in PHC patients was analyzed.The diagnostic value of single and combined detection of NLR and serum AFP,GP73 and DKK1 in PHC patients was analyzed by ROC curve.Results:The levels of NLR and serum AFP,GP73 and DKK1 in each group were in turn PHC group,LC group,CHB group and control group.There were significant differences between the two groups (P＜0.05).The levels of NLR and serum AFP,GP73 and DKK1 in different stages of TNM in PHC patients were in the order of stage Ⅳ,Ⅲ,Ⅱ and Ⅰ.There were significant differences between the two groups (P＜0.05).The results of ROC curve showed that the area under the curve of NLR and serum AFP,GP73 and DKK1 levels in diagnosing PHC was 0.859,0.698,0.775 and 0.901,respectively.The best cut-off values were 10.25,12.39 ng/mL,115.87 ng/mL and 5.36 ng/mL.The sensitivity was 75.70%,61.40%,65.70%,85.70%.Specificity was 85.70%,71.40%,78.60% and 80.00%,respectively.The area under the curve of NLR combined with serum AFP,GP73 and DKK1 levels was 0.941.The sensitivity was 88.60%,and the specificity was 92.90%.The diagnostic efficiency of NLR combined with serum AFP,GP73 and DKK1 levels was better than that of single diagnosis of PHC.Conclusion:The levels of NLR in peripheral blood and AFP,GP73 and DKK1 in serum of patients with PHC are significantly increased.The combined detection of the four can improve the diagnostic efficiency of PHC.

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Memo

Memo:

National Natural Science Foundation of China(No.81673165）；国家自然科学基金(编号：81673165)

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