|Table of Contents|

Expression and clinical significance of FOXP1 and PBRM1 in colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
770-775
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of FOXP1 and PBRM1 in colon cancer
Author(s):
Li Yongliang
Gastrointestinal Surgery Department,the Affiliated Hospital of Putian University,Fujian Putian 351100,China.
Keywords:
colon cancerFOXP1PBRM1clinical significance
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2020.05.017
Abstract:
Objective:To investigate the expression of FOXP1 and PBRM1 in colon cancer tissues and paracancerous tissues,and to analyze their relationships with clinicopathological characteristics and prognosis of colon cancer.Methods:The colon cancer tissues and corresponding paracancerous tissues of 75 patients with colon cancer were selected.The expression levels of FOXP1 and PBRM1 genes were detected by qRT-PCR.The protein expression of FOXP1 and PBRM1 was detected by immunohistochemistry.The influence of FOXP1 and PBRM1 expression on survival rate of colon cancer patients was calculated by Kaplan-Meier.Correlation between FOXP1 and PBRM1 expression was analyzed by Spearman correlation analysis.Cox regression model was used to analyze the prognostic factors of colon cancer.Results:Compared with paracancerous tissues,the expression level of FOXP1 gene in colon cancer tissues was up-regulated,and the expression level of PBRM1 gene was down-regulated,with statistical significances (P<0.01).The positive expression rates of FOXP1 and PBRM1 in colon cancer tissues were 65.33% and 41.33% respectively,and the positive expression rates of FOXP1 and PBRM1 in paracancerous tissues were 24.00% and 77.33% respectively.Compared with paracancerous tissues,the positive expression of FOXP1 in colon cancer tissues increased significantly,and the positive expression of PBRM1 decreased significantly,with statistical significances (P<0.05).The expression of FOXP1 and PBRM1 was not correlated with age,gender and tumor size (P>0.05),but was correlated with TNM stage,differentiation degree and lymph node metastasis (P<0.05).The survival rate of patients with FOXP1 positive expression was significantly lower than that of patients with negative expression (P<0.05),and the survival rate of patients with PBRM1 positive expression was significantly higher than that of patients with negative expression (P<0.05).The survival rate of patients with FOXP1 positive expression was significantly lower than that of PBRM1 positive expression patients (P<0.05).Spearman correlation analysis results showed there was a negative correlation between FOXP1 and PBRM1 expression (r=-0.547,P<0.05).Cox regression model analysis showed that FOXP1 and PBRM1 were independent factors affecting the prognosis of colon cancer patients.Conclusion:FOXP1 and PBRM1 are abnormally expressed in colon cancer.Both are involved in the occurrence and development of colon cancer.They may become new tumor markers for the diagnosis and treatment of colon cancer.

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