|Table of Contents|

Efficacy and prognostic analysis of Cyberknife treatment for peripheral non-small cell lung cancer in early stage

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
766-770
Research Field:
Publishing date:

Info

Title:
Efficacy and prognostic analysis of Cyberknife treatment for peripheral non-small cell lung cancer in early stage
Author(s):
Deng Lijun12Pan Xuefeng2Liu Jia2Zheng Guobao12
1.Xinxiang Medical University,Henan Xinxiang 453000,China;2.No.150 Central Hospital of PLA,Henan Luoyang 471031,China.
Keywords:
peripheral non-small cell lung cancer in early stagestereotactic body radiotherapyCyberknifeefficacyprognosis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.05.016
Abstract:
Objective:To evaluate the efficacy and prognostic factors of Cyberknife treatment for peripheral non-small cell lung cancer (NSCLC) in early stage.Methods:46 patients with early stage NSCLC (including 11 cases of stageⅠpatients and 35 cases of stageⅡpatients) were treated with Cyberknife from October 2010 to September 2016 in our hospital.The total dose of irradiation was 36~60 Gy,and the PTV was covered by the 64%~85% isodose line.The total number of therapy was 3~12 times,and all patients were treated with irradiation once a day and five times a week.Results:All patients were followed up from 1 month to 94 months after treatment.Short-term efficacy results showed that the efficient rate and the control rate were 84.8 % and 93.5 %,respectively.The local median progression-free survival (PFS) was 40.0 months (95%CI:35.9~54.9),and the median overall survival (OS) was 43.0 months (95%CI:40.1~57.3).The local control rate for one year was 91.3%.The 1-year,3-year and 5-year survival rates were 91.3%,58.5% and 26.3%,respectively.There was no serious side effect during or after treatment in all patients.Multivariate analysis of Cox model showed that gross target volume (GTV) and biologic effective dose (BED) were independent prognostic indicators of OS in patients with early stage NSCLC.Conclusion:Cyberknife is an efficient and safe option for early stage NSCLC,especially for stageⅠpatients with small lesion,which may achieve a better clinical results than surgery.

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