|Table of Contents|

The advance of treatment in triple-positive breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
687-690
Research Field:
Publishing date:

Info

Title:
The advance of treatment in triple-positive breast cancer
Author(s):
Zhang Guotai12Fu Deyuan2
1.Dalian Medical University,Liaoning Dalian 116044,China;2.Department of Thyroid and Breast Surgery,Northern Jiangsu People's Hospital,Jiangsu Yangzhou 225001,China.
Keywords:
triple-positivebreast cancertherapy
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2020.04.039
Abstract:
Triple-positive breast cancer is one of the special molecular subtype of breast cancer,characterized by the expression of ER,PR,HER-2,sensitive to chemotherapy,targeted therapy,endocrine therapy.Theoretically,combination therapy for its effect would be more effective,however,the treatment of TPBC did not achieve the desired prognosis.The future research should focus on the exploration of characteristics,resistance mechanism and targeted therapy.

References:

[1]Chen WQ,H Li,KX Sun,et al.Report of cancer incidence and mortality in China,2014[J].Chinese Journal of Cancer,2018,40(1):5-13.
[2]Vici P,L Pizzuti,C Natoli,et al.Triple positive breast cancer:A distinct subtype[J]?Cancer Treat Rev,2015,41(2):69-76.
[3]Ellis MJ,Y Tao,O Young,et al.Estrogen-independent proliferation is present in estrogen-receptor HER-2-positive primary breast cancer after neoadjuvant letrozole[J].J Clin Oncol,2006,24(19):3019-3025.
[4]Anderson WF,PS Rosenberg,A Prat,et al.How many etiological subtypes of breast cancer:Two,three,four,or more[J]?Breast Diseases A Year Book Quarterly,2015,26(4):296-297.
[5]Popovska S,I Ivanov.Lymphatic vascularization in primary breast cancer:HER-2 overexpressing tumors contain more lymphatics than steroid receptor positive,triple-positive and triple negative breast carcinomas[J].Turk Patoloji Derg,2014,30(2):124-132.
[6]Kast K,T Link,K Friedrich,et al.Impact of breast cancer subtypes and patterns of metastasis on outcome[J].Breast Cancer Res Treat,2015,150(3):621-629.
[7]Iancu G,D Vasile,RC Iancu,et al."Triple positive" breast cancer - a novel category[J]?Rom J Morphol Embryol,2017,58(1):21-26.
[8]Fedele P,N Calvani,A Marino,et al.Targeted agents to reverse resistance to endocrine therapy in metastatic breast cancer:Where are we now and where are we going[J]?Crit Rev Oncol Hematol,2012,84(2):243-251.
[9]Murphy BL,CN Day,TL Hoskin,et al.Neoadjuvant chemotherapy use in breast cancer is greatest in excellent responders:Triple-negative and HER-2(+) subtypes[J].Ann Surg Oncol,2018,25(8):2241-2248.
[10]Darb-Esfahani S,S Loibl,BM Muller,et al.Identification of biology-based breast cancer types with distinct predictive and prognostic features:Role of steroid hormone and HER-2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy[J].Breast Cancer Res,2009,11(5):R69.
[11]Hurvitz SA,M Martin,WF Symmans,et al.Pathologic complete response (pCR) rates after neoadjuvant trastuzumab emtansine (T-DM1
[K]) + pertuzumab (P) vs docetaxel + carboplatin + trastuzumab + P (TCHP) treatment in patients with HER-2-positive (HER-2+) early breast cancer (EBC) (KRISTINE)[J].Journal of Clinical Oncology,2016,34(15_suppl):500.
[12]Rimawi M,R Cecchini,P Rastogi,et al.Abstract S3-06:A phase III trial evaluating pCR in patients with HR+,HER-2-positive breast cancer treated with neoadjuvant docetaxel,carboplatin,trastuzumab,and pertuzumab (TCHP) +/- estrogen deprivation:NRG Oncology/NSABP B-52[J].Cancer Research,2017,77(4 Supplement):S3-06.
[13]Li J,Z Shao,B Xu,et al.Use of trastuzumab as an adjuvant/neoadjuvant therapy in patients with HER-2-positive breast cancer in China:The Nvwa study[J].Medicine (Baltimore),2018,97(21):e10350.
[14]Ellis MJ,VJ Suman,J Hoog,et al.Ki67 proliferation index as a tool for chemotherapy decisions during and after neoadjuvant aromatase inhibitor treatment of breast cancer:Results from the american college of surgeons oncology group Z1031 Trial (Alliance)[J].J Clin Oncol,2017,35(10):1061-1069.
[15]Gradishar WJ,BO Anderson,R Balassanian,et al.Breast cancer,version 4.2017,NCCN clinical practice guidelines in oncology[J].J Natl Compr Canc Netw,2018,16(3):310-320.
[16]Bonifazi M,M Franchi,M Rossi,et al.Long term survival of HER-2-positive early breast cancer treated with trastuzumab-based adjuvant regimen:A large cohort study from clinical practice[J].Breast,2014,23(5):573-578.
[17]Harbeck N.Advances in targeting HER-2-positive breast cancer[J].Curr Opin Obstet Gynecol,2018,30(1):55-59.
[18]Krop IE,SB Kim,A González.Trastuzumab emtansine versus treatment of physician's choice for pretreated HER-2-positive advanced breast cancer (TH3RESA):A randomised,open-label,phase 3 trial[J].Lancet Oncology,2014,15(7):689.
[19]Goss PE,JN Ingle,KI Pritchard,et al.A randomized trial (MA.17R) of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer[J].Journal of Clinical Oncology,2016,34(18_suppl):LBA1.
[20]Goss PE.Extending endocrine therapy in women with hormone receptor-positive breast cancer[J].Clinical Advances in Hematology & Oncology,2015,13(1):20-22.
[21]Blok EJ,JR Kroep,KE Meershoek-Klein,et al.Optimal duration of extended adjuvant endocrine therapy for early breast cancer,results of the IDEAL trial (BOOG 2006-05)[J].Journal of the National Cancer Institute,2018,110(1):40-48.
[22]Alqaisi A,L Chen,E Romond,et al.Impact of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER-2) co-expression on breast cancer disease characteristics:Implications for tumor biology and research[J].Breast Cancer Res Treat,2014,148(2):437-444.
[23]Vici P,L Pizzuti,I Sperduti,et al."Triple positive" early breast cancer:An observational multicenter retrospective analysis of outcome[J].Oncotarget,2016,7(14):17932-17944.
[24]Seiffert K,B Schmalfeldt,V Muller.Current status of targeted treatment in breast cancer[J].Dtsch Med Wochenschr,2017,142(22):1669-1675.
[25]Ellis MJ,A Llombartcussac,D Feltl,et al.Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer:Overall survival analysis from the phase II first study[J].J Clin Oncol,2015,33(32):3781-3787.
[26]Baselga J,M Campone,M Piccart,et al.Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer[J].N Engl J Med,2012,366(6):520-529.
[27]Kornblum N,Zhao F,Manola J,et al.Everolimus enhances the efficacy of fulvestrant in ER(+) breast cancer[J].Cancer Discov,2018,8(6):14.
[28]Sparano JA.Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane[J].J Clin Oncol,2010,28(20):3256.
[29]WANG Y,JIA WJ,RAO NY,et al.Comparison of the early or late use of capecitabine-based regimens for treatment of metastatic breast cancer[J].Chinese Journal of Cancer Prevention and Treatment,2016,23(15):1006-1010.[汪颖,贾卫娟,饶南燕,等.含卡培他滨方案一线或后线治疗晚期乳腺癌的疗效比较[J].中华肿瘤防治杂志,2016,23(15):1006-1010.]
[30]Ramakrishna N,S Temin,S Chandarlapaty,et al.Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases:ASCO clinical practice guideline update[J].J Clin Oncol,2018,14(8):505-507.
[31]Swain SM,SB Kim,J Cortés,et al.Pertuzumab,trastuzumab,and docetaxel for HER-2-positive metastatic breast cancer (CLEOPATRA study):Overall survival results from a randomised,double-blind,placebo-controlled,phase 3 study[J].Lancet Oncology,2013,14(6):461.
[32]Blackwell KL,HJ Burstein,AM Storniolo,et al.Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer:Final results from the EGF104900 study[J].J Clin Oncol,2012,30(21):2585-2592.
[33]Gianni L,T Pienkowski,YH Im,et al.Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced,inflammatory,or early HER-2-positive breast cancer (NeoSphere):A randomised multicentre,open-label,phase 2 trial[J].Lancet Oncology,2012,13(1):25-32.
[34]Gianni L,G Bisagni,M Colleoni,et al.Neoadjuvant treatment with trastuzumab and pertuzumab plus palbociclib and fulvestrant in HER-2-positive,ER-positive breast cancer (NA-PHER-2):An exploratory,open-label,phase 2 study[J].Lancet Oncol,2018,19(2):249-256.

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Last Update: 2019-12-26