|Table of Contents|

Advances in the application of hypomethylating agents combined with Venetoclax in hematopoietic stem cell transplantation for acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 10
Page:
1929-1934
Research Field:
Publishing date:

Info

Title:
Advances in the application of hypomethylating agents combined with Venetoclax in hematopoietic stem cell transplantation for acute myeloid leukemia
Author(s):
GAO Yunfei1ZHAO Xin2WANG Yong1LIU Xiaoliang1
1.Department of Hematology;2.Department of Pediatrics,the First Hospital of Jilin University,Jilin Changchun 130061,China.
Keywords:
hypomethylating agentsVenetoclaxcombined therapyacute myeloid leukemiaallo-HSCT
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2024.10.030
Abstract:
Relapse after transplantation is the main reason for the failure of allo-HSCT in acute leukemia.Salvage treatment for patients with relapses is limited,the prognosis is often poor,and few patients can survive for a long time.The treatment of hypomethylating agents (HMAs) in combination with Veneolax (VEN) has become a new standard treatment scheme recommended by guidelines for patients ≥ 60 years old,especially for newly diagnosed acute myeloid leukemia (AML) patients who are not suitable for intensive treatment.However,the combined treatment of HMAs+VEN in allo-HSCT is rarely used in clinics.This article reviews the role of the combination of the two in bridging allo-HSCT,prevention of recurrence after transplantation,and salvage treatment,to clarify the overall efficacy of the treatment of AML transplant patients,and further guide its clinical application in allo-HSCT.

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Memo:
吉林省自然科学基金(学科布局项目)(编号:20210101250JC,20200201594JC)
Last Update: 1900-01-01