|Table of Contents|

Bioinformatics analysis on molecular mechanism of active compound of green tea(EGCG) in treatment of ovarian cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 10
Page:
1481-1487
Research Field:
Publishing date:

Info

Title:
Bioinformatics analysis on molecular mechanism of active compound of green tea(EGCG) in treatment of ovarian cancer
Author(s):
Zhang Mu1; Song Xinqiang2; 3; Zhang Yafang2; Chen Lei2; Lee Yew Mun3
1.Hospital Attached to Xinyang Normal University,Henan Xinyang 464000,China;2.Department of Biological Sciences,Xinyang Normal University,Henan Xinyang 464000,China;3.Department of Biological Sciences,National University of Singapore,Kent Ridge 117543,Singapore.
Keywords:
epigallocatechin-3-gallate(EGCG); ovarian cancer; Ingenuity Pathway Analysis(IPA); PubChem
PACS:
R730.54
DOI:
10.3969/j.issn.1672-4992.2018.10.001
Abstract:
Objective:To study the molecular mechanism of active compound of green tea(EGCG) in the treatment of ovarian cancer．Methods:Target proteins of EGCG related genes of ovarian cancer were searched from PubChem and Gene databases online respectively．Canonical pathways and molecular networks comparison analyses were performed by IPA．Results:There were 232 common pathways in EGCG target proteins and ovarian cancer related gene,and top 3 shared signaling pathway primarily involve molecular mechanisms of cancer,inflammation,and cytokine signaling.There were 6 common networks focused on cell death and survival,cellular growth and proliferation,cellular development,DNA replication,recombination and repair,post-transcriptional modifications,and protein synthesis.In the pathway,we proposed that Jun,FADD,NF-κB,BCL2,HIF1α,and MMP act as the reacting sites for EGCG to treat ovarian cancer.Conclusion:EGCG treated ovarian cancer by regulating many targets of cancer related signal pathways．

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Memo

Memo:
National Natural Science Foundation of China（No.81502312）；国家自然科学基金资助项目（编号：81502312）
Last Update: 2018-04-02