|Table of Contents|

Research progress on the role of hyaluronan in the regulation of tumor cell plasticity

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 06
Page:
1172-1176
Research Field:
Publishing date:

Info

Title:
Research progress on the role of hyaluronan in the regulation of tumor cell plasticity
Author(s):
LIU Qinqing1LIU Yiwen2HE Yiqing2DU Yan2ZHANG Guoliang2GAO Feng2YANG Cuixia12
1.Department of Clinical Laboratory;2.Department of Molecular Biology,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China.
Keywords:
hyaluronantumor cell plasticitytumor cell stemnessEMTtumor multidrug resistance
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2024.06.035
Abstract:
Hyaluronan (HA) is an important component of extracellular matrix,which can abnormally accumulate in tumor stroma.HA plays an important role in the reconstruction of tumor microenvironment.It is reported that HA,its metabolic enzymes and receptors were closely related to tumor cell plasticity.HA participates in the regulation of the cell stemness maintenance,epithelial to mesenchymal transition (EMT) and acquired multidrug resistance.This article will summarize and discuss HA' s role in the regulation of tumor cell plasticity.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81974445,82273462);国家自然科学基金项目(编号:81974445,82273462)
Last Update: 1900-01-01