|Table of Contents|

Research progress on TRBC1 as a potential target for the treatment of T-cell tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 06
Page:
1163-1166
Research Field:
Publishing date:

Info

Title:
Research progress on TRBC1 as a potential target for the treatment of T-cell tumors
Author(s):
ZHOU MengLI Hui
Department of Hematology,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Hubei Wuhan 430000,China.
Keywords:
TCRTRBC1diagnosis of hematological tumorsCAR-T cell therapyT cell activation signal transduction
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2024.06.033
Abstract:
T-cell tumors are aggressive,easily resistant and have a poor prognosis,and the recurrence rate is high after conventional treatment,and there are currently no specific drugs for their treatment.If early diagnosis and treatment methods can be improved,it will effectively improve the prognosis of patients.Cellular immunotherapy achieves a high cure rate for B-cell-derived hematologic tumors.However,due to the lack of suitable targets,immunotherapy for the treatment of T cell-derived hematologic tumors is not effective.The newly discovered TRBC1 as a potential therapeutic target brings hope for the diagnosis and treatment of T-cell tumors.This article will review the current research progress of TRBC1 in disease diagnosis and cellular immunotherapy.

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Memo

Memo:
National Natural Science Foundation of China(No.82370196);国家自然科学基金(编号:82370196);湖北省教育厅科学研究计划中青年人才项目(编号:Q20211113);武汉市科技局知识创新专项曙光计划项目(编号:2022020801020313)
Last Update: 1900-01-01