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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 05

Page:

895-899

Research Field:

Publishing date:

Info

Title:

Monomorphic epitheliotropic intestinal T-cell lymphoma:4 cases report and literature review

Author(s):

PU Zhenhong; FENG Jianglong; PEI Yuanyuan; YANG Wenxiu

Department of Pathology,Affiliated Hospital of Guizhou Medical University£¬Guizhou Guiyang 550001£¬China.

Keywords:

MEITL; clinicopathological characteristics; treatment; prognosis

PACS:

R733.4

DOI:

10.3969/j.issn.1672-4992.2024.05.019

Abstract:

Objective:To investigate the clinicopathological characteristics,clinical diagnosis and treatment,and prognosis of monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL) based on previous case reports and literature review.Methods£ºThe clinical diagnosis and treatment process,histomorphological characteristics,immunohistochemical phenotype,molecular pathological results,treatment process and prognosis of 4 cases of MEITL were retrospectively analyzed,and the previous case reports and review literature were combined to summarize and analyze.Results£ºThe 4 cases reported in this paper were all middle-aged and elderly patients,3 cases were male,1 case was female,4 cases had tumors in the small intestine,and case 3 was accompanied by sigmoid colon tumors.The main clinical manifestations were abdominal pain,intestinal obstruction,intestinal perforation,and pelvic and peritoneal effusion.Histomorphologically,medium to large heterotypic lymphocytes diffusely infiltrated the whole layer of intestinal wall,and obvious intestinal crypts and epithelial growth of tumors in the surface epithelium were observed.The expression of CD3,CD43,TIA1,granzyme B,and Bcl-2 in METIL tumor cells was detected by immunohistochemistry,and EBER in situ hybridization was negative.T lymphocyte gene rearrangement was positive in 4 cases.Conclusion£ºThe incidence rate of MEITL is low.It often occurs in the small intestine of middle-aged and elderly men,and has no specific clinical symptoms.The final diagnosis can be made only by combining the clinical manifestations,histological and morphological characteristics,immunohistochemical phenotype and molecular pathological results.The prognosis of MEITL is extremely poor and progresses rapidly.There is no effective treatment plan for MEITL.It is necessary to improve the understanding and diagnosis of the disease.

References:

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Last Update: 2024-01-30