|Table of Contents|

Research progress on the relationship between tumor-associated gene alterations and tertiary lymphoid structures formation and its effect on tumor prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 04
Page:
758-766
Research Field:
Publishing date:

Info

Title:
Research progress on the relationship between tumor-associated gene alterations and tertiary lymphoid structures formation and its effect on tumor prognosis
Author(s):
CHE Yurou1; 2; YANG Man1; 2; LI Kezhen2; 3; DONG Juan3; 4; LI Simin2; 3; ZHANG Yiyao1; 2; XU Zhu2; 3; WANG Mei1; 2; LUO Liping1; 5; FANG Zengyi1; 2; 5; WU Chuan1
Keywords:
tertiary lymphoid structures; malignant tumor; gene; tumor microenvironment
PACS:
R730.231
DOI:
10.3969/j.issn.1672-4992.2024.04.031
Abstract:
In recent years,several studies have shown that tertiary lymphoid structures(TLS) are associated with good prognosis and immunotherapy efficacy in most malignant tumors and play an important role in clinical treatment options.But the relationship between tumor-associated gene alterations and TLS has rarely been investigated.What is the specific role of gene alterations in the regulation of TLS induction? In this paper,we will review the composition,structure and formation mechanism of TLS,relationship between tumor-associated gene alterations and TLS,impact on tumor prognosis,as well as future perspectives to understand the function of TLS and the potential role of gene alterations in it in more detail,to provide a relevant basis for clinical precision therapy and the development of new drugs.

References:

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四川省自然科学基金重点项目（编号：2022NSFSC0051）；四川省肿瘤医院临床科学家项目（编号：YB2022003）；四川省成都市技术创新研发项目（编号：2021YF0501659SN）
Last Update: 1900-01-01