|Table of Contents|

The relationship between preoperative ALI and prognosis of patients undergoing radical cystectomy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 04
Page:
720-723
Research Field:
Publishing date:

Info

Title:
The relationship between preoperative ALI and prognosis of patients undergoing radical cystectomy
Author(s):
YANG Hao; WEI Weiyang; ZHOU Chuanpeng; WANG Qi; HUANG Hongxing; HUANG Yaqiang
Department of Urology Surgery,Zhongshan People's Hospital,Guangdong Zhongshan 528499,China.
Keywords:
bladder cancer; radical cystectomy; advanced lung cancer inflammation index; prognosis
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2024.04.023
Abstract:
Objective:To explore the correlation between the advanced lung cancer inflammatory index (ALI) and the prognosis of patients undergoing radical cystectomy (RC).Methods:To analyze the clinical data of 115 patients who underwent radical cystectomy in our hospital from April 2012 to March 2021,including basic information,preoperative hematology examination,histopathology and survival.The receiver operating characteristic was used to determine the optimal threshold value of ALI (29.49) and the patients were divided into low ALI group (46 cases) and high ALI group (69 cases).The survival curve was established by Kaplan Meier method.Log Rank test was used to compare the overall survival (OS) of patients between groups.Cox regression analysis was used to analyze the prognostic factors of patients undergoing radical cystectomy.Results:A total of 115 patients were included,including 103 males and 12 females.T1 phase(47 cases),＞T1 phase (68 cases).Pathological grade ≤G2 (38 cases),G3 (77 cases).N0 stage (106 cases),>N0 stage (9 cases).Univariate analysis showed that ALI,T stage,tumor pathological grade,N stage,neutrophil-to-lymphocyte ratio (NLR),white blood cells,and neutrophils were associated with OS,with Wald values of 25.504,22.458,20.013,15.779,22.645,6.098,and 14.137,respectively,all P＜0.05.Multivariate analysis showed that low ALI (HR=2.387,95%CI 1.085~5.236,Wald=4.673,P＜0.05),T stage (HR=2.796,95%CI 1.381~5.662,Wald=8.163,P＜0.01),and tumor pathological grade (HR=2.907,95%CI 1.315~6.427,Wald=6.949,P＜0.01) were independent risk factors for patient OS.The median OS of patients in the low ALI group and high ALI group before surgery was 14 months and>50 months,respectively.The OS of patients in the low ALI group was significantly lower than that in the high ALI group,and the difference was statistically significant(χ2=29.825，P＜0.01).Conclusion:Preoperative low ALI is an independent risk factor for OS in patients undergoing radical cystectomy,and preoperative ALI can serve as a new prognostic indicator for patients undergoing radical cystectomy.

References:

［1］ SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2021,71(3):209-249.
［2］ 黄健，张旭.中国泌尿外科和男科疾病诊断治疗指南［M］.北京：科学出版社，2022：64-73. HUANG J,ZHANG X.Guidelines for the diagnosis and treatment of urological and andrological diseases in China［M］.Beijing:Science Press,2022:64-73.
［3］ TSAI YT,HSU CM,CHANG GH,et al.Advanced lung cancer inflammation index predicts survival outcomes of patients with oral cavity cancer following curative surgery［J］.Front Oncol,2021,11:609314.
［4］ YIN C,TOIYAMA Y,OKUGAWA Y,et al.Clinical significance of advanced lung cancer inflammation index,a nutritional and inflammation index,in gastric cancer patients after surgical resection:a propensity score matching analysis［J］.Clin Nutr,2021,40(3):1130-1136.
［5］ SONG M,ZHANG Q,SONG C,et al.The advanced lung cancer inflammation index is the optimal inflammatory biomarker of overall survival in patients with lung cancer［J］.J Cachexia Sarcopenia Muscle,2022,13(5):2504-2514.
［6］ KUSUNOKI K,TOIYAMA Y,OKUGAWA Y,et al.Advanced lung cancer inflammation index predicts outcomes of patients with colorectal cancer after surgical resection［J］.Colorectal Dis,2020,63(9):1242-1250.
［7］ LU Y,JIANG JW,REN CX.The clinicopathological and prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in small cell lung cancer:a meta-analysis［J］.PLoS One,2020,15(4):e0230979.
［8］ JAKUBOWSKA K,KODA M,KISIELEWSKI W,et al.Pre and postoperative neutrophil and lymphocyte count and neutrophil to lymphocyte ratio in patients with colorectal cancer［J］.Mol Clin Oncol,2020,13(5):1.
［9］ KIM J,BAE JS.Tumor-associated macrophages and neutrophils in tumor microenvironment［J］.Mediators Inflamm,2016,2016:6058147.
［10］ ETHIER JL,DESAUTELS D,TEMPLETON A,et al.Prognostic role ofneutrophil-to-lymphocyte ratio in breast cancer:a systematic review and meta-analysis［J］.Breast Cancer Res,2017,19(1):1-13.
［11］ DU S,FANG Z,YE L,et al.Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy［J］.Aging (Albany NY),2021,13(13):17638.
［12］ ZHOU Y,WEI Q,FAN J,et al.Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer:A meta-analysis containing 8252 patients［J］.Clin Chim Acta,2018,479:181-189.
［13］ WANG J,SHI H,FAN Z,et al.Prognostic nutritional index combined with NLR to construct a survival prediction model and decision analysis of patients with muscle-invasive bladder cancer after surgery［J］.Cancer Med,2023,12:14207-14224.
［14］ SALAS S,COTTET V,DOSSUS L,et al.Nutritional factors during and after cancer:Impacts on survival and quality of life［J］.Nutrients,2022,14:undefined.
［15］ HUA X,CHEN J,WU Y,et al.Prognostic role of the advanced lung cancer inflammation index in cancer patients:a meta-analysis［J］.World J Surg Oncol,2019,17(1):1-9.

Memo

Memo:
广东省中山市科技计划项目(编号：2019B1062，2019B1063)
Last Update: 1900-01-01