|Table of Contents|

Influencing factors of autologous peripheral blood hematopoietic stem cell mobilization and collection in patients with non-Hodgkin' s lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 02
Page:
304-308
Research Field:
Publishing date:

Info

Title:
Influencing factors of autologous peripheral blood hematopoietic stem cell mobilization and collection in patients with non-Hodgkin' s lymphoma
Author(s):
LIANG Xiao1; Xianmusiya·Maimaitirexiati1; ZHENG Xiaoyan2; WANG Xiaoning2; WEN Shujuan1
1.Department of Lymphoma,the Affiliated Tumor Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011,China;2.Department of Hematology,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China.
Keywords:
non-Hodgkin's lymphoma; autologous peripheral blood stem cell transplantation; stem cell mobilization and collection
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2024.02.019
Abstract:
Objective:To determine the factors affecting the mobilization and collection of autologous peripheral blood hematopoietic stem cells (APBSC) in patients with non-Hodgkin's lymphoma (NHL).Methods:The clinical data of 85 NHL patients who received the mobilization and collection of APBSC in the Department of Hematology of the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to June 2020 were collected.The effects of gender,age,disease type,Ann Arbor stage,pre-transplant disease status,International Prognostic Index (IPI) score,chemotherapy cycle,and different schemes on APBSC collection were analyzed by univariate and multivariate Logisitic regression.Results:Univariate analysis showed that there was no correlation between the age,disease type,Ann Arbor stage,disease status and the number of CD34+ cells collected or the collection success rate (P＞0.05).Male patients had more CD34+cells than female patients (P=0.01).Chemotherapy cycles ≤4 times before mobilization were favorable factors for collection (P＜0.05).CHOP-E and CHOP-MTX combined with G-CSF mobilization schemes could be used as effective mobilization schemes for APBSC.Multivariate results showed that the number of chemotherapy cycles before collection was an independent factor affecting the success of hematopoietic stem cell collection,and the number of chemotherapy cycles>4 times before mobilization was a negative factor for the success of hematopoietic stem cell collection.Conclusion:Compared with CHOP-E+G-CSF,CHOP-MTX+G-CSF mobilized more CD34+ cells.Male patients and those with fewer chemotherapy cycles before mobilization collection are more conducive to the mobilization and collection of autologous peripheral blood hematopoietic stem cells in NHL patients.

References:

［1］ 孙艳，郭莉，胡欣，等.大剂量化疗联合自体造血干细胞移植治疗68例淋巴瘤临床疗效分析［J］.中华肿瘤防治杂志,2019,26(13):963-968. SUN Y,GUO L,HU X,et al.Clinical analysis of high-dose chemotherapy combined with autologous hematopoietic stem cell transplantation for treatment of lymphoma［J］.Chinese Journal of Cancer Prevention and Treatment,2019,26(13):963-968.
［2］ 平措卓嘎，左旭盈，王剑利，等.化疗序贯自体造血干细胞移植治疗淋巴瘤的疗效评价及影响因素分析［J］.现代肿瘤医学,2022,30(3):509-513. PING CZG,ZUO XY,WANG JL,et al.Efficacy evaluation and influencing factors of autologous hematopoietic stem cell transplantation following chemotherapy in the treatment of lymphoma［J］.Modern Oncology,2022,30(3):509-513.
［3］ PARTANEN A,TURUNEN A,VALTOLA J,et al.Mobilization characteristics,blood graft composition,and outcome in diffuse large,the prospective multicenter GOA study［J］.Transfusion,2021,61(2):516-525.
［4］ SONNEVELD P,SCHMIDT-WOLF IG,VAN DER HOLT B,et al.Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma:results of the randomized phase Ⅲ HOVON-65/GMMG-HD4 trial［J］.J Clin Oncol,2012,30(3):2946-2955.
［5］ 余先球，王丽霞，雷芳，等.淋巴瘤及骨髓瘤患者自体外周造血干细胞动员相关影响因素分析［J］.中国实验血液学杂志,2022,30(6):1861-1867. YU XQ,WANG LX,LEI F,et al.Analysis of related factors of autologous peripheral hematopoietic stem cell mobilization in patienets with lymphoma and myeloma［J］.Journal of Experimental Hematology,2022,30(6):1861-1867.
［6］ 苏永锋，王艺志，宁红梅，等.淋巴瘤与多发性骨髓瘤患者自体外周血造血干细胞动员影响因素分析［J］.中国实验血液学杂志,2021,29(6):1945-1949. SU YF,WANG YZ,NING HM,et al.Analysis of factors influencing autologous peripheral blood stem cells mobilization in patients with lymphoma and multiple myeloma［J］.Journal of Experimental Hematology,2021,29(6):1945-1949.
［7］ PUSIC I,JIANG SY,LANDUA S,et al.Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous ransplantation［J］.Biol Blood Marrow Transplant,2008,14(9):1045-1056.
［8］ 陈晓,郭智,陈丽娜,等.自体外周血造血干细胞动员采集的影响因素［J］.中国组织工程研究,2021,25(19):2958-2962. CHEN X,GUO Z,CHEN LN,et al.Factors affecting the mobilization and collection of autologous peripheral blood hematopoietic stem cells［J］.Chin J Tissue Engineering Research,2021,25(19):2958-2962.
［9］ 王国蓉，陈文明，李燕郴，等.149例多发性骨髓瘤患者自体外周血造血干细胞动员采集的回顾性分析［J］.中华血液学杂志,2015,36(5):367-371. WANG GR,CHEN WM,LI YC,et al.A retrospective analysis of autologous peripheral blood hematopoietic stem cell mobilizations and collections in 149 multiple myeloma patients ［J］.Chinese Journal of Hematology,2015,36(5):367-371.
［10］ ROSSI G,SKERT C,MORELLO E,et al.PBSC mobilization in lymphoma patients:analysis of risk factors for collection failure and development of a predictive score based on the kinetics of circulating CD34+ cells and WBC after chemotherapy and GCSF mobilization［J］.Hematol Oncol,2015,33(3):125-132.
［11］ 鲍文,刘苒,王飞,等.恶性血液系统疾病自体外周血造血干细胞动员的临床分析［J］.中国实验血液学杂志,2020,28(2)：663-668. BAO W,LIU R,WANG F,et al.Clinical analysis of autologous peripheral blood hematopoietic stem cell mobilization regimen in patients with malignant hematological diseases［J］.Journal of Experimental Hematology,2020,28(2)：663-668.
［12］ MICALLEF IN,APOSTOLIDIS J,ROHATINER AZ,et al.Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma［J］.Hematol J,2000,1(6):367-373.
［13］ DONMEZ A,YILMAZ F,GOKMEN N,et al.Risk factors for a poor hematopoietie stem cell mobilization［J］.Transfus Apher Sci,2013,49(3):485-488.
［14］ 赵志强,王列样,刘小兰,等.自体外周血干细胞动员及采集效果影响因素分析［J］.白血病·淋巴瘤,2019,28(9):533-537. ZHAO ZQ,WANG LX,LIU XL,et al.Analysis of factors influencing the mobilization and collection of autologous peripheral blood stem cells［J］.Journal of Leukemia & Lymphoma,2019,28(9):533-537.
［15］ STIFF PJ,UNGER JM,COOK JR,et al.Autologons transplantation as consolidation for aggressive non-Hodgldn's lymphoma［J］.N Engl J Med,2013,369(18):1681-1690.
［16］ 郑志海,廖丽昇,曲双,等.非霍奇金淋巴瘤采用BEAM方案预处理行自体外周血干细胞移植治疗的临床分析［J］.中国现代医生,2021,59(22):86-89. ZHENG ZH,LIAO LS,QU S,et al.Clinical analysis of BEAM regimen pretreatment for autologous peripheral blood stem cell transplantation in treatment of non-Hodgkin's lymphoma［J］.China Modern Doctor,2021,59(22):86-89.
［17］ 熊艺颖,陈建斌,刘林,等.IEAC或CEAC预处理方案用于淋巴瘤自体造血干细胞移植的疗效与安全性比较［J］.南方医科大学学报,2020,40(12):1760-1767. XIONG YY,CHEN JB,LIU L,et al.IEAC versus CEAC high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation for lymphoma:analysis of efficacy and safety［J］.Journal of Southern Medical University,2020,40(12):1760-1767.
［18］ WOOD WA,WHITLEY J,GOYAL R,et al.Effectiveness of etoposide chemomobilization in lymphoma patients undergoing auto-SCT［J］.Bone Marrow Transplant,2013,48(6):771-776.

Memo

Memo:
新疆维吾尔自治区自然科学基金项目(编号：2021D01C416);自治区科技支疆项目计划(指令性)项目(编号:2022E02053)
Last Update: 1900-01-01