|Table of Contents|

Prognostic value of geriatric nutritional risk index during neoadjuvant chemotherapy in elderly patients with gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 02
Page:
289-296
Research Field:
Publishing date:

Info

Title:
Prognostic value of geriatric nutritional risk index during neoadjuvant chemotherapy in elderly patients with gastric cancer
Author(s):
DUAN Yingxin; HUO Junjie
Department of Radiotherapy and Chemotherapy,the Second Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054000,China.
Keywords:
gastric cancer; neoadjuvant chemotherapy; geriatric nutritional risk index; short-and long-term prognosis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2024.02.016
Abstract:
Objective:To investigate the prognostic value of geriatric nutritional risk index (GNRI) during neoadjuvant chemotherapy in predicting short-and long-term prognosis of elderly patients with gastric cancer (GC).Methods：The clinicopathological data of 230 elderly GC patients who underwent neoadjuvant chemotherapy combined with radical gastrectomy at our institution between January 2014 and December 2019 were retrospectively reviewed.The receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of the GNRI on short-and long-term efficacy.The Logistic and Cox regression models were used to identify the independent risk factors for short-and long-term prognosis.The interaction terms between the GNRI and clinicopathological factors were constructed and P values for interaction were calculated.The long-term prognostic value of GNRI in subgroups was analyzed.Results：Compared with the GNRI before neoadjuvant chemotherapy and the change of GNRI during neoadjuvant chemotherapy,the GNRI after neoadjuvant chemotherapy (post-GNRI) had the highest predictive abilities in predicting postoperative complications,3-year overall survival (OS),and 3-year disease-free survival (DFS),with the AUC values of 0.692,0.703,and 0.702,respectively.Compared with the patients with a higher post-GNRI,the patients with a lower post-GNRI had significantly longer time to ambulation,time to first flatus,time to first diet,and postoperative hospital stay,as well as a significantly higher rate of postoperative complications (33.6% vs 20.5%) (all P＜0.05).Multivariate analysis showed that a low post-GNRI was an independent risk factor for postoperative complications and poor long-term prognosis(all P＜0.05).Moreover,subgroup analysis showed that the post-GNRI exhibited a better prognostic value in patients with yp stage I-II disease.Conclusion:The GNRI after neoadjuvant chemotherapy was an independent predictor of both short-and long-term prognosis.Patients with a higher GNRI had fewer postoperative complications,faster recovery,and prolonged survival periods.

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Memo:
河北省邢台市重点研发计划项目（编号：2020ZC382）
Last Update: 1900-01-01