|Table of Contents|

Integrins and its application in the treatment of multiple myeloma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1153-1156
Research Field:
Publishing date:

Info

Title:
Integrins and its application in the treatment of multiple myeloma
Author(s):
ZHENG DongZHU MingxiaJING Hongmei
Department of Hematology,Peking University Third Hospital,Beijing 100191,China.
Keywords:
integrinmultiple myelomatherapeutic target
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2023.06.034
Abstract:
Multiple myeloma is a malignant plasma cell tumor,despite significant improvements in survival with new drugs,some patients still face the challenges of relapse and drug resistance,and the disease remains incurable.Integrins and their ligands play important roles in leukocyte adhesion,proliferation,migration and signal transduction.Recent studies have found that integrin is highly expressed on the surface of multiple myeloma tumor cells,which mediates the adhesion and metastasis of tumor cells,leads to cell adhesion-mediated drug resistance and indicates poor prognosis.As multiple myeloma enters the era of targeted therapy,the therapeutic and prognostic value of integrins has gained attention and is expected to become a new therapeutic target in multiple myeloma.In this paper,we review the current status of research on integrins in multiple myeloma.

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北京康盟慈善基金会医学科研发展基金项目临床与基础研究专项(编号:TB211020)
Last Update: 1900-01-01