|Table of Contents|

Research progress on the role of WWP2 in tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1142-1148
Research Field:
Publishing date:

Info

Title:
Research progress on the role of WWP2 in tumor
Author(s):
XU Haiqi; ZHANG Lijun
Department of Hematology，the First Hospital of China Medical University，Liaoning Shenyang 110000，China.
Keywords:
WWP2; UPS; E3 ubiquitin ligases; tumor
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.06.032
Abstract:
WWP2 is one of the members of the E3 ligases of coding Nedd4 family，contains the WW domain of E3 ubiquitin protein ligase 2,which can bind to the target protein to play a corresponding role.With the increase of WWP2 research in recent years,it is found that WWP2 is not only related to stem cell self-renewal and immune system,but also has functions in many diseases,especially in tumor.WWP2 can serve as a biomarker of tumor progression and prognosis,providing potential therapeutic targets for the development of new antitumor drugs.This review mainly elucidates the structure and related function of WWP2,as well as the important roles in various diseases.

References:

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