|Table of Contents|

The prognostic value of APRI score in patients with HBV-associated hepatocellular carcinoma undergoing hepatectomy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1079-1085
Research Field:
Publishing date:

Info

Title:
The prognostic value of APRI score in patients with HBV-associated hepatocellular carcinoma undergoing hepatectomy
Author(s):
ZHOU Yunxiang1; JIANG Yanji2; GONG Wenfeng2; MO Qiuyan1; LIU Yingchun2; ZHOU Zihan2; LONG Meiying1; CHEN Peiqin2; LIN Qiuling2; WEN Qiuping2; ZHOU Xianguo<
1.School of Public Health,Guangxi Medical University,Guangxi Nanning 530021,China;2.Guangxi Medical University Cancer Hospital,Guangxi Nanning 530021,China.
Keywords:
aspartate aminotransferase to platelet ratio index(APRI); hepatocellular carcinoma(HCC); hepatitis B virus(HBV); overall survival(OS); nomogram
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2023.06.018
Abstract:
Objective：To evaluate the predictive value of the aspartate aminotransferase to platelet ratio index(APRI) for postoperative overall survival (OS) in patients undergoing resection for HBV-associated hepatocellular carcinoma (HCC).Methods:Used retrospective cohort study,we collected the preoperative clinical data of 1 031 patients with HBV-related HCC who underwent radical surgery in Guangxi Medical University Cancer Hospital from January 2012 to December 2016.The optimal cutoff value of APRI was obtained by Kaplan-Meier survival curve.Kaplan-Meier method was used to draw survival curves,and Log-rank test was used to compare the survival of groups with different levels of APRI.The independent influencing factors of OS were screened by stepwise multivariate Cox regression.The correlation between APRI and the risk of mortality was evaluated by restricted cubic spline(RCS).The ability of APRI to predict OS was evaluated by establishing nomogram and verify it internally.Results:RCS showed a non-linear correlation between APRI and the risk of mortality(non-linear P＜0.001).Multivariate Cox regression showed that APRI,BCLC stage,AFP,gender and tumor size were independent influencing factors of OS,and the risk of death in the group with high APRI was 2.1 times higher than that in the group with low APRI.The nomogram of patients' OS showed that APRI was second only to BCLC staging in predicting OS.The C-index of the OS nomogram was 0.71 (95%CI:0.68~0.74) in the train group and 0.69 (95%CI:0.64~0.75) in the test group.The 1 and 5-year OS correction curves showed that the nomogram model had good calibration.DCA curve showed that the model had good clinical application value.Conclusion:APRI is an independent factor affecting the OS of patients undergoing HBV-related HCC resection.Patients are stratified according to APRI for individualized treatment and follow-up.

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Memo

Memo:
广西科技计划项目（编号：AB18050020，AA18221001）；广西自然科学基金（编号：2018GXNSFDA050012）；上海市吴孟超医学科学基金（编号：JJHXM-2019042）；广西医科大学青年科学基金（编号：GXMUYSF202121）
Last Update: 1900-01-01