|Table of Contents|

Difference of expression and clinical significance of mismatch repair proteins in left and right colon cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
126-129
Research Field:
Publishing date:

Info

Title:
Difference of expression and clinical significance of mismatch repair proteins in left and right colon cancer tissues
Author(s):
ZHONG Li; LIU Qianqian; QU Yanli
Department of Gastroenterology,the Third Clinical Affiliated Tumor Hospital of Xinjiang Medical University，Xinjiang Urumchi 830011,China.
Keywords:
left colon cancer; right colon cancer; mismatch repair protein; clinicopathological characteristics; prognosis
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2023.01.023
Abstract:
Objective:To investigate the expression of mismatch repair(MMR) protein in left colon cancer(LCC) and right colon cancer(RCC) and its clinical significance.Methods:The clinicopathological data of 368 colon cancer patients who underwent surgical treatment in our hospital from January 2014 to December 2017 were collected.According to the primary tumor site,they were divided into LCC group and RCC group,and the MMR protein was analyzed.Whether there were significant differences in the expression of left and right colon cancer tissues,the clinicopathological characteristics of left and right colon cancers were discussed at the same time,and the guiding significance of MMR protein to the prognosis of left and right colon cancers was analyzed.Results:The incidence rate of dMMR in 368 colon cancer tissues was 25.8%.The results of single factor analysis showed that the incidence of MMR protein in different tumor sites was significantly different(P＜0.05).The expression rate of dMMR in RCC group was 17.4%,which was significantly higher than the 8.4% of the LCC group.In addition,there were statistical differences in tumor diameter,differentiation degree,and histological type between LCC and RCC(all P＜0.05).Logistic multivariate analysis found that tumor diameter≥5 cm(OR=1.762,95%CI:1.144～2.713,P=0.010),dMMR(OR=2.672,95%CI:1.617～4.417,P=0.000) were independent factors related to RCC.Kaplan-Meier survival analysis showed that the OS of the dMMR group was significantly higher than that of the pMMR group(P=0.035).After stratified analysis of tumor location,the OS of dMMR patients in the RCC group was significantly higher than that of pMMR patients(P=0.004),but in the LCC group,there was no significant difference in OS between dMMR patients and pMMR patients(P=0.951).Conclusion:The incidence of dMMR in RCC is significantly higher than that in LCC,and it only suggests a better prognostic effect in RCC,but no prognostic indicator in LCC.

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Last Update: 2022-11-30