|Table of Contents|

The safety and efficacy of transanal local excision with endoscopic linear cutters for the treatment of T1 stage mid-low rectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
121-125
Research Field:
Publishing date:

Info

Title:
The safety and efficacy of transanal local excision with endoscopic linear cutters for the treatment of T1 stage mid-low rectal cancer
Author(s):
WU Wenlong; ZHANG Shuai; FU Zhijun; BI Renjie; LI Shuguang
Department of Gastrointestinal Oncology,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China.
Keywords:
T1 stage; mid-low rectal cancer; endoscopic linear cutters; transanal local excision
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2023.01.022
Abstract:
Objective:To investigate the clinical efficacy and safety of transanal local excision with endoscopic linear cutters(ENDOPATH) among T1 stage mid-low rectal cancer patients.Methods:92 patients admitted with T1 stage mid-low rectal cancer in our hospital were collected from January 2011 to December 2017.According to the surgical methods,patients were divided into transanal local excision group(TAE group) and traditional radical therapy group(radical group).39 patients in the TAE group underwent transanal full-thickness local excision with ENDOPATH.53 patients in the radical group underwent conventional radical surgery according to the principle of total mesorectal excision,including 16 patients with Miles and 37 patients with Dixon.Comparative analyses of basic materials,intraoperative and postoperative indicators,and prognosis status were performed between the two groups.Result:The TAE group and radical group had no significant differences in gender,age,postoperative pathological types,tumor size,and tumor distance from the anal verge(P＞0.05).General characteristic of patients were comparable between the two groups.The two groups had significant differences in operation time［TAE group:(37.74±10.66)min,radical group:(117.66±41.78)min］,postoperative hospital stay［TAE group:(6.85±1.06)days,radical group:(10.70±1.72)days］,intraoperative bleeding volume［TAE group:(30.21±2.97)mL,radical group:(78.96±12.65)mL］,and the rate of postoperative complications(TAE group:2.56%,radical group:43.39%)(P＜0.01).In both groups,the 3-year disease-free survival was 100.00% and there was no recurrence.There was no statistical differences between the two groups(P＞0.05).The two groups had significant differences in the score of survival quality［TAE group:（90.31±3.82）scores,radical group:(71.59±6.33)scores］(P＜0.01).Conclusion:For T1 stage mid-low rectal cancer cases,transanal local excision with ENDOPATH may achieve the same clinical efficacy and safety as conventional radical surgery.Compared with the conventional radical surgery,transanal local excision with ENDOPATH has obvious advantages of less trauma,fewer surgical complications,quicker recovery and higher living quality.Transanal local excision with ENDOPATH may be a preferentially selective for no lymph metastasis in early mid-low rectal cancer.

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河北省医学科学研究重点课题计划（编号：20160373）;河北省医学科学院研究计划项目（编号：20220583）
Last Update: 2022-11-30