|Table of Contents|

Different types of anemia before colorectal cancer surgery relationship with tumor characteristics,systemic inflammation and survival

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
94-99
Research Field:
Publishing date:

Info

Title:
Different types of anemia before colorectal cancer surgery relationship with tumor characteristics,systemic inflammation and survival
Author(s):
LI Wenqiang; XU Guoshuai; YAO Nan; WANG Dezhong; QU Jun
Aerospace Center Hospital，Beijing 100049，China.
Keywords:
anemia; inflammation; colorectal cancer; risk factors; prognosis
PACS:
R735.5+5
DOI:
10.3969/j.issn.1672-4992.2023.01.017
Abstract:
Objective:To explore the relationship between tumor characteristic parameters and systemic inflammatory response of colorectal cancer patients with different anemia types before surgery.As well as the prognosis of colorectal cancer patients with different types of anemia before surgery.Methods:The clinical data of 118 patients with colorectal cancer who were admitted to the general surgery department of aereospace hospital from January 2013 to December 2015 were retrospectively analyzed.According to the hemoglobin(Hb),mean corpusular volume(MCV),mean corpsular hemoglobin(MCH),and mean corpuscular hemoglobin concentration(MCHC),the patients were divided into no-anemia group,microcytic anemia group,and normocytic anemia group.The general data,oncological characteristics and mGPS scores of the three groups were compared and analyzed.The patients were followed up for 5 years after operation and survival was observed.The survival curve was plotted by kaplan-Meier method.Survival analysis was performed using Log-rank test.Univariate and multivariate analyses of prognostic factors were performed in patients with colorectal cancer using Cox proportional hazards regression model.Results:The preoperative anemia rate of colorectal cancer patients in this study was 45.8%(54/118).Among the patients with different anemia types before surgery,there were statistically significant differences in gender,body mass reduction,CA724,tumor site,tumor size,TNM stage,mGPS score and Ki-67 expression rate(P＜0.05).The 5-year survival rate of the no-anemia group was 59.4% and the average survival time was 49 months.In microcytic anemia group,the 5-year survival rate was 29.4% and the average survival time was 34 months.The 5-year survival rate of normocytic anemia group was 35.1% and the average survival time was 41 months.The survival time of the no-anemia group was compared with the microcytic anemia group and the normocytic anemia group,and the difference was statistically significant(χ2=5.462，P=0.019,χ2=4.187，P=0.041).Univariate analysis showed that tumor marker CA199,tumor size,TNM stage,presence or absence of distant metastasis,lymph node metastasis,mGPS score,Ki-67 positive expression rate,and anemia type were related factors affecting the prognosis of colorectal cancer patients(P＜0.05).Multivariate analysis showed that tumor size,TNM stage,presence or absence of distant metastasis,mGPS score,Ki-67 positive expression rate,and anemia type were independent risk factors affecting the prognosis of colorectal cancer patients(P＜0.05).Conclusion:The preoperative colorectal cancer patients with different types of anemia have different oncological characteristics.And systemic inflammation may be related to the state of preoperative anemia.Preoperative anemia and systemic inflammation are independent risk factors for the prognosis of patients with colorectal cancer.Therefore,in the preoperative preparation phase of patients,anemia and systemic inflammation should be restored and improved as much as possible to obtain a better prognosis of colorectal cancer and prolong the survival time of patients.

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Last Update: 2022-11-30