|Table of Contents|

Analysis of clinical features and prognostic factors of hemophagocytic syndrome (27 cases attached)

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 04
Page:
689-692
Research Field:
Publishing date:

Info

Title:
Analysis of clinical features and prognostic factors of hemophagocytic syndrome (27 cases attached)
Author(s):
LI Yeqiong; YE Xiupeng; WANG Jiayi; Muhtar?Yimamniyaz; MA Jian; BAO Shen
People’s Hospital of Ningxia Hui Autonomous Region，First Affiliated Hospital of Northwest University for Nationalities,Ningxia Yinchuan 750002,China.
Keywords:
hemophagocytic syndrome; fever; ferritin; NK cell activity; splenomegaly; prognostic factors
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2022.04.026
Abstract:
Objective:To explore the laboratory examination results of hemophagocytic syndrome (HPS) and its correlation analysis with prognosis,so as to improve the understanding of hemophagocytic syndrome and the relevant factors affecting prognosis.Methods:The etiology,clinical manifestations,laboratory results and outcomes of 27 patients with HPS from January 2012 to January 2020 were retrospectively analyzed.Results:Among the 27 patients,10 patients were malignant associated HPS,9 patients infection associated HPS,3 patients autoimmune disease associated HPS,1 patient primary HPS with UNC13D mutation,and 4 patients with unknown etiology.The coincidence rate of HLH-2004 diagnosis standard of each index included:Fever,elevated ferritin，NK cell activity decreased or absent (100%),2 or 3 cytopenia (92.59%),sCD25 increased (90.91%),splenomegaly (85.19%),fibrinogenemia (77.78%),hypertriglyceridemia (74.07%),hemophagocytes (72.22%).The differences in platelet,fibrinogen,serum ferritin and lactate dehydrogenase levels between the survival group and the death group were statistically significant (P＜0.05).Multivariate analysis showed that thrombocytopenia was an independent prognostic risk factor(OR=0.955，95%CI:0.917~0.996,P=0.031).Conclusion:The clinical manifestations of HPS are diverse.The disease progresses rapidly.The mortality is high.Fever,at least two lines of blood cell hypoxia,NK cell activity decreased,ferritin and sCD25 levels significantly increased have high sensitivity in the diagnosis.Increased AST and β2-MG,reduced HDL cholesterol,and hyponatremia are beneficial to the diagnosis of HPS.Thrombocytopenia is an independent prognostic risk factor.

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Memo

Memo:
宁夏自然科学基金项目资助（编号：2018AAC03174）；宁夏人民医院振兴培育项目（编号：201920）
Last Update: 1900-01-01