|Table of Contents|

Effect of head and neck radiotherapy on oral microflora

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
499-504
Research Field:
Publishing date:

Info

Title:
Effect of head and neck radiotherapy on oral microflora
Author(s):
HU Yang1; WEI Hao2; HE Yinbo1; SUN Yu1; ZHU Jiang2
1.Department of Radiotherapy,Cancer Center;2.Department of Thoracic Oncology,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China.
Keywords:
head and neck tumor; radiation-induced oral mucositis; oral microflora; radiotherapy
PACS:
R739.91
DOI:
10.3969/j.issn.1672-4992.2022.03.025
Abstract:
Objective:This study aims to explore the variation of oral microflora in patients with head and neck cancer undergoing radiotherapy,and the association between the changes of oral microflora with the different degrees of radiation-induced oral mucositis.Methods:Twenty patients with head and neck cancer who received radiotherapy from November 2019 to April 2020 in one hospital were selected.Eligible patients received the dynamic intensity-modulated radiotherapy with the radiation dose of 6 996 cGy.Oral saliva,buccal mucosa,and pharyngeal swabs were collected at 0~19 Gy,20~39 Gy,and 40 Gy of the cumulative dose of radiotherapy.The lllumina sequencing technology was performed to detect the composition and diversity of microbial communities.Results:In the salivary flora,the relative abundance of Firmicutes and Proteobacteria increased with the accumulation of radiation dose.The relative abundance of Thaumarchaeota,Euryarchaeota,Crenarchaeotadecreased significantly with the increase of radiation dose.The relative abundance of Firmicutes,Bacteroidetes,and Fusobacteria in buccinal mucosa decreased with the degree of mucositis increasing,while the relative abundance of Actinobacteria increased with the degree of mucositis increasing.The relative abundance of Firmicutes and Actinomycetes in the salivary flora was positively correlated with the severity of mucositis,while the relative abundance of other high-abundance flora was negatively correlated with the severity of mucositis.Conclusion:As the cumulative dose of radiotherapy increases,the RIOM classification of tumor patients gradually increases,the relative abundance of oral salivary flora changes,and the alpha diversity decreases.The degree of mucositis aggravate,the relative abundance of buccal mucosa and salivary flora change greatly,and alpha diversity decreases.

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Last Update: 2021-12-31