|Table of Contents|

Research progress on the role of GPX3 DNA methylation in the development and progression of malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 01
Page:
167-171
Research Field:
Publishing date:

Info

Title:
Research progress on the role of GPX3 DNA methylation in the development and progression of malignant tumors
Author(s):
SONG MinLI YongWANG YananZHANG YiyiGE XinJIANG MeijingLI Qi
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
GPX3DNA methylationepigeneticmalignant tumor
PACS:
R730.54
DOI:
10.3969/j.issn.1672-4992.2022.01.037
Abstract:
In recent years,changes in tumor epigenetics have become attractive targets for cancer treatment and prevention,and the most common and widespread epigenetic pathway is DNA methylation.Studies have found that glutathione peroxidase 3(glutathione peroxidase 3,GPX3)acts as a selenoprotein with antiviral and diverse tumors in vivo,GPX3 mRNA and or)down-regulation or even silencing of protein expression is associated with hypermethylation of the GPX3 gene promoter,and down-regulation of GPX3 expression after DNA methylation can reduce the clearance of peroxidation products in the body,which in turn leads to accumulation of peroxide in the body,eventually causing the occurrence and development of tumors.

References:

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Last Update: 2021-12-02