|Table of Contents|

Pulmonary Langerhans' s cell histocytosis based on tissue biopsy emphasis:A comprehensive analysis of pathological classification and prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 01
Page:
61-64
Research Field:
Publishing date:

Info

Title:
Pulmonary Langerhans' s cell histocytosis based on tissue biopsy emphasis:A comprehensive analysis of pathological classification and prognosis
Author(s):
QIN Yaping1; 2; XU Xinyun1; FAN Xiangshan1; WANG Jingmei1; YU Huiping1; SHI Jiong1
1.Department of Pathology,the Affiliated Drum Tower Hospital of Medical School of Nanjing University,Jiangsu Nanjing 210008,China;2.Department of Pathology,the Second Affiliated Hospital of Guilin Medical University,Guangxi Guilin 541199,China.
Keywords:
lung; Langerhans cell; histiocytosis; pneumothorax
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2022.01.013
Abstract:
Objective:To summarize the clinicopathological features and prognosis of pulmonary Langerhans' cell histiocytosis(PLCH),improve the rate of diagnosis and reduce the adverse prognosis.Methods:7 cases of PLCH confirmed by pathology at the hospital in Nanjing in 2002 to 2019 years were retrospectively analysed.The origin,clinical features,pathological characteristics and prognosis of the tissue were discussed.Results:The age of 7 patients ranged from 18 to 61 years(average 33 years).The ratio of male/female was 5/2.Cough and chest tightness were the first symptoms in 6 patients.One patient was diagnosed with double lung bullae due to back pain.3 cases of thoracic CT showed diffuse lesions of two lungs,and 4 cases showed a change of unilateral pneumothorax.Histological cluster of Langerhans cells were accompanied by an unequal amount of eosinophilic granulocytes,lymphocytes,tissue cells and neutrophils infiltration.Surrounding lung tissue showed fibrous tissue hyperplasia and emphysema,lung vesicles formation.Immunohistochemical staining of Langerhans cells expressed Langerin,S-100 and CD1a.Most of the cases(4/7) had no smoking history.Follow-up of 6 cases of primary PLCH showed survival,stable condition and no progress.One case of multisystem PLCH(involving lung and bone) died of respiratory failure 18 months later.Conclusion:PLCH is rare.Clinical symptoms lack specificity.Misdiagnosis and missed diagnosis were common.For young and middle-aged patients with respiratory symptoms and no smoking,when chest imaging examination indicates pneumothorax or diffuse lesions,PLCH should be vigilant.Thoracoscopic lung biopsy or partial pneumonectomy followed by pathological examination can make a definite diagnosis.The prognosis of elderly patients with diffuse pulmonary nodules and multiple systems is poor.

References:

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Last Update: 2021-12-02