|Table of Contents|

Advances of researches on the role of MLLT3 in acute leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1079-1082
Research Field:
Publishing date:

Info

Title:
Advances of researches on the role of MLLT3 in acute leukemia
Author(s):
ZHANG XinyuLYU HanningZHAO WenhaoSUN Lichun
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
MLLT3MLL-MLLT3 translocationacute leukemia
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2021.06.039
Abstract:
MLLT3 is a histone covalent modifications by chromatin-binding protein modules and a critical component of the super elongation complex. In addition,MLLT3 plays pivotal roles in the regulation of chromatin remodelling and gene expression of many important proto-oncogenes via histone modification.MLLT3 translocation into the MLL-MLLT3 fusion gene contributes to acute leukemia.In this review,we have summarized what is currently known about the structure and function of the MLLT3 molecule. We described the physiological role of MLLT3 and the pathological effects on the development of acute leukemia,as well as the emerging knowledge of MLLT3 as an epigenetic therapeutic target,providing new ideas for the diagnosis and treatment of acute leukemia.

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