|Table of Contents|

Research progress of NSD2 in prostate cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1076-1079
Research Field:
Publishing date:

Info

Title:
Research progress of NSD2 in prostate cancer
Author(s):
ZHANG JiajiaSHI Guangyue
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
NSD2prostate cancermetastasistreatment
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2021.06.038
Abstract:
Nuclear receptor binding SET domain-protein 2 (NSD2) is a member of the HMTases family,and its SET domain mainly catalyzes the dimethylation of histone H3 lysine at position 36 (H3K36) to further play the role of gene regulation.As an important regulatory mechanism in epigenetics,histone methylation plays an important role in transcriptional regulation,chromatin remodeling and other biological processes.Some reports have described NSD2 as an oncogene,which is highly expressed in a variety of tumors and is associated with tumor malignancy and prognosis.The high expression of NSD2 in prostate cancer not only promotes the occurrence and development of prostate cancer,but also promotes its invasion and metastasis.Further exploration of the mechanism of NSD2 will promote the development of relevant targeted drugs and provide new treatment schemes for prostate cancer.

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