|Table of Contents|

The study on the application of one-step spectral and perfusion CT imaging in the diagnosis of lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1032-1035
Research Field:
Publishing date:

Info

Title:
The study on the application of one-step spectral and perfusion CT imaging in the diagnosis of lung cancer
Author(s):
LI Lin; LUO Yahong
Department of Medical Imaging,Cancer Hospital of China Medical University,Liaoning Cancer Hospital & Institute,Liaoning Shenyang 110042,China.
Keywords:
lung cancer; pathological type; perfusion imaging; spectral imaging
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2021.06.028
Abstract:
Objective:To investigate the application value of one-step spectral and perfusion imaging with Aquilion ONE 640-slice CT scanner in the diagnosis of lung cancer.Methods:Patients with confirmed pulmonary nodules who were collected and underwent one-step spectral and perfusion imaging.Pathologically confirmed lesions were 24 squamous cell carcinomas,29 adenocarcinomas,and 8 small cell lung cancers.After the images were acquired,the energy spectrum data of each group was processed in the Dual Energy processing program,the iodine concentration (IC) of the lesion and the aorta in the same layer were measured in the generated iodine map,and the standardized iodine concentration (NIC) was abtained.CT perfusion images were reconstructed by primary perfusion data and 80 kVp energy level images which generated from spectral CT through Vitrea workstation.CT perfusion parameters included arterial flow (AF),pulmonary flow (PF) and perfusion index (PI).All the aforem entioned data were measured three times and averaged.Comparison of energy spectrum and perfusion parameter difference between lung squamous cell carcinoma and adenocarcinoma were analyzed by adopting independent sample t test,and parameters with statistical differences were further analyzed by receive operating characteristic (ROC) curve.The difference (P＜0.05) was considered statistically significant.Results:The IC,NIC,AF,and PF in lung adenocarcinoma were higher than that in lung squamous cell carcinoma,and PI was lower than that in lung squamous cell carcinoma group.Additionally,statistically significant differences were found for IC,NIC,AF,and PI between two types of lung cancer(P＜0.05),and the AUC were 0.717,0.899,0.79,0.746,respectively.When IC,NIC,AF and PI were combined for in the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma,the AUC was 0.943,and the sensitivity and specificity were 86.2% and 95.8%,respectively.Conclusion:The difference in IC,NIC,AF,and PI values between lung adenocarcinoma and lung squamous cell carcinoma were statistically significant,and the combination of four parameter values could improve the diagnostic sensitivity and specificity.One-step spectral and perfusion imaging is feasible in the assessment of lung squamous cell carcinoma and adenocarcinoma.

References:

［1］CAO M,CHEN W.Epidemiology of lung cancer in China［J］.Thoracic Cancer,2019,10(1):3-7.
［2］KNIGHT SB,CROSBIE PA,BALATA H,et al.Progress and prospects of early detection in lung cancer［J］.Open Biology,2017,7(9):170070.
［3］周静宜,刘芸,黄劲柏.宝石能谱CT成像在不同病理类型肺癌分类诊断的价值探讨［J］.CT理论与应用研究,2017,26(03):291-298. ZHOU JY,LIU Y,HUANG JB.The value of spectral CT image in the diagnosis of different pathological types of lung cancer［J］.CT Theory and Applications,2017,26(3):291-298.
［4］CHEN ML,LI XT,WEI YY.Can spectral computed tomography imaging improve the differentiation between malignant and benign pulmonary lesions manifesting as solitary pure ground glass,mixed ground glass,and solid nodules［J］.Thoracic Cancer,2019,10(2):235-242.
［5］WU LY,CAO GQ,ZHAO L.Spectral CT analysis of solitary pulmonary nodules for differentiating malignancy from benignancy:The value of iodine concentration spatial distribution difference［J］.BioMed Research International,2018,2018:1-9.
［6］郭剑波.能谱CT成像在孤立性肺结节良恶性鉴别诊断中的应用价值研究［J］.中国CT和MRI杂志,2017,15(02):54-57. GUO JB.Application value study of spectral CT imaging on differential diagnosis of benign and malignant of SPN［J］ .Chinese Journal of CT and MRI,2017,15(02):54-57.
［7］SUN Y,YANG M,MAO D,et al.Low-dose volume perfusion computed tomography (VPCT) for diagnosis of solitary pulmonary nodules［J］.European Journal of Radiology,2016,85(6):1208-1218.
［8］VALENTIN J.International commission on radiation protection managing patient dose in multi-detector computed tomography(MDCT).ICRP publication 102［J］ .Annals of the Icrp,2007,37(1):1-79.
［9］陈兆渤.首过双入口灌注CT成像在诊断孤立性肺结节的作用研究［D］.吉林：延边大学,2017. CHEN ZB.Clinical research of first pass dual-input perfusion CT imaging in the diagnosis of solitary pulmonary nodule［D］.Jilin:Yanbian University,2017.
［10］吴柯薇,钟朝辉,王振常,等.宽体探测器CT不同扫描方式对胸部低剂量CT图像质量及辐射剂量的影响［J］.中国医疗设备,2019,34(08):93-96. WU KW,ZHONG ZH,WANG ZC,et al.Effect of scan method on low dose chest CT image quality and radiation dose［J］.China Medical Equipment,2019,34(08):93-96.
［11］宁志光,马国峰,于远，等.宽体探测器 CT 多物质伪影降低技术对 CT 扫描图像质量的影响［J］.中华放射学杂志,2017,51(10):790-793. NING ZG,MA GF,YU Y,et al.The effect of a multi-material artifact reduction algorithm in a wide-detector CT system to reduce the beam hardening artifacts in CT imaging ［J］.Chinese Journal of Radiology,2017,51(10):790-793.
［12］WANG GL,ZHANG CQ,LI MY,et al.Preliminary application of high-definition computed tomographic gemstone spectral imaging in lung cancer［J］.Journal of Computer Assisted Tomography,2014,38(1):77-81.
［13］陈盈,姚婷,郑昊,等.CT能谱在原发性肺癌病理分型中的应用［J］.医学影像学杂志,2016,26(07):1222-1225. CHEN Y,YAO T,ZHENG H,et al.Applications of gemstone spectrum CT in pathological type of primary lung cancer［J］.Journal of Medical Imaging,2016,26(07):1222-1225.
［14］宁先英,李浩,杨明,等.CT能谱定量分析对肺腺癌与鳞癌的鉴别诊断价值［J］.放射学实践,2017,32(3):237-241. NING XY,LI H,YANG M,et al.Value of spectral CT quantitative analysis in the differential diagnosis of pulmonary adenocarcinoma and squamous cell carcinoma［J］.Radiol Practice，2017,32(3)：237-241.
［15］李琦.能谱CT定量分析在评估肺癌病理组织学特征中的应用研究［D］.重庆：重庆医科大学，2016. LI Q.The application study on quantitative analysis of histopathological features of lung cancer with spectral CT［D］.Chongqing:Chongqing Medical University,2016.
［16］高垒,杨青,胡亚彬,等.双入口CT灌注评价肺腺癌和肺鳞癌血供特征［J］.中国医学影像技术,2017,33(03):419-422. GAO L,YANG Q,HU YB,et al.Assessment of bronchial and pulmonary blood supply in lung adenocarcinoma and squamous cell carcinoma using dual-input perfusion CT［J］.Chinese Journal of Medical Imaging Technology,2017,33(03):419-422.
［17］NGUYEN-KIM TD,FRAUENFELDER T,STROBEL K,et al.Assessment of bronchial and pulmonary blood supply in non-small cell lung cancer subtypes using computed tomography perfusion ［J］.Invest Radiol，2015，50(3):179-186.
［18］马泽鹏,敖国昆,袁小东,等.肺癌双循环血供CT灌注的初步研究［J］.临床放射学杂志,2015,34(02):204-207. MA ZP,AO GK,YUAN XD,et al．Evaluation of CT perfusion scanning in diagnosing lung cancer receiving dual blood supply:A preliminary study ［J］.Journal of Clinical Radiology,2015,34(02):204-207.

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辽宁省恶性肿瘤临床医学研究中心（编号：2018416029）
Last Update: 1900-01-01