|Table of Contents|

Investigation of HPV infection in esophageal squamous cell carcinoma patients in Hefei area and the relationship between HR-HPV infection and prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
964-968
Research Field:
Publishing date:

Info

Title:
Investigation of HPV infection in esophageal squamous cell carcinoma patients in Hefei area and the relationship between HR-HPV infection and prognosis
Author(s):
WU Lili; TIAN Jing; WANG Hongqun; WANG Qingmei; LI Xuemin
The Third People's Hospital of Hefei,Anhui Hefei 230032,China.
Keywords:
esophageal squamous cell carcinoma; human papillomavirus; high risk type; prognosis
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2021.06.012
Abstract:
Objective:To investigate the infection of human papillomavirus (HPV) in patients with esophageal squamous cell carcinoma in Hefei area,and to explore the relationship between high risk HPV (HR-HPV) infection and prognosis.Methods:384 patients with esophageal squamous cell carcinoma(including esophageal squamous intraepithelial neoplasia with canceration) in Hefei admitted in our hospital from June 2013 to February 2019 were selected,who were detected for HPV.HPV infection in the patients included in the study were analyzed statistically,and the patients were divided into good prognosis group and poor prognosis group according to the prognosis followed up for 1 year after operation/radiotherapy and chemotherapy,then the relationship between HR-HPV infection and the prognosis of esophageal squamous cell carcinoma patients was also analyzed by multivariate Logistic analysis.Results:In 384 cases of esophageal squamous cell carcinoma,the infection rate of HPV was 36.72%,of which the low-risk HPV infection accounted for 9.93%,of which the HR-HPV accounted for 90.07%,and the genotypes from high to low were 16,18,52,33,6,51,58 and 11 respectively.During the follow-up of 1 year,the poor prognosis rate of 384 esophageal squamous cell carcinoma patients was 57.03% (219/384),and the HR-HPV infection rate in the poor prognosis group was significantly higher than that in the good prognosis group (P＜0.05).Logistic analysis showed that the poorly or undifferentiated or moderately differentiated cancer,clinical stage Ⅳ or Ⅲ,lymph node metastasis,drinking history and HR-HPV infection were the risk factors for the poor prognosis of esophageal squamous cell carcinoma (OR=3.916,2.581,4.080,3.238,4.821,2.986,3.062,P＜0.05).Conclusion:There are high HPV infection rate in patients with esophageal squamous cell carcinoma in Hefei area,and HPV16 and HPV18 and other high-risk types are the main types,and HR-HPV infection can increase the risk of poor prognosis in patients with esophageal cancer.

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