|Table of Contents|

Research progress of androgen receptor and endocrine resistance in breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
524-527
Research Field:
Publishing date:

Info

Title:
Research progress of androgen receptor and endocrine resistance in breast cancer
Author(s):
WANG JiamingLI NingningTANG YiSU Rong
Department of Breast Sugery,the Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China.
Keywords:
androgen receptorbreast cancerendocrine resistanceprognosis
PACS:
R737.9
DOI:
DOI:10.3969/j.issn.1672-4992.2021.03.037
Abstract:
Breast cancer is the most common malignancies in females.Estrogen receptor(ER) positive breast cancer is sensitive to endocrine therapy,and the risk of recurrence and death is significantly reduced by standardized endocrine therapy.However,endocrine resistance has become the biggest obstacle in clinical treatment.Androgen receptor(AR)is widely expressed in ER-positive breast cancer,and there is the crosstalk between AR and ER,which affects cancer development,endocrine resistance and prognosis.This article reviews the role of AR in mechanism,prognosis and endocrine therapy,especially endocrine resistance in ER-positive breast cancer.

References:

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Memo

Memo:
广东省医学科学技术研究基金项目(编号:A2016441)
Last Update: 2021-01-02