[1]BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[2]EBCTCG EBCT.Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:An overview of the randomised trials[J].Lancet,2005,365(9472):1687-1717.
[3]SZOSTAKOWSKA M,TREBINSKA-STRYJEWSKA A,GRZYBOWSKA EA,et al.Resistance to endocrine therapy in breast cancer:Molecular mechanisms and future goals[J].Breast Cancer Research and Treatment,2019,173(3):489-497.
[4]HAQUE MM,DESAI KV.Pathways to endocrine therapy resistance in breast cancer[J].Frontiers in Endocrinology,2019,10(1):573-580.
[5]LI W,O' SHAUGHNESSY J,HAYES D,et al.Biomarker associations with efficacy of abiraterone acetate and exemestane in postmenopausal patients with estrogen receptor-positive metastatic breast cancer[J].Clinical Cancer Research,2016,22(24):6002-6009.
[6]HICKEY TE,IRVINE CM,DVINGE H,et al.Expression of androgen receptor splice variants in clinical breast cancers[J].Oncotarget,2015,6(42):44728-44744.
[7]CIMINO-MATHEWS A,HICKS JL,ILLEI PB,et al.Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy[J].Hum Pathol,2012,43(7):1003-1011.
[8]PONNUSAMY S,ASEMOTA S,SCHWARTZBERG LS,et al.Androgen receptor is a non-canonical inhibitor of wild-type and mutant estrogen receptors in hormone receptor-positive breast cancers[J].iScience,2019,21:341-358.
[9]HE L,DU Z,XIONG X,et al.Targeting androgen receptor in treating HER2 positive breast cancer[J].Sci Rep,2017,7(1):14584-14593.
[10]GUCALP A,TOLANEY S,ISAKOFF SJ,et al.Phase II trial of bicalutamide in patients with androgen receptor-positive,estrogen receptor-negative metastatic breast cancer[J].Clin Cancer Res,2013,19(19):5505-5512.
[11]MCNAMARA KM,MOORE NL,HICKEY TE,et al.Complexities of androgen receptor signalling in breast cancer[J].Endocr Relat Cancer,2014,21(4):161-181.
[12]SULTANA A,IDRESS R,NAQVI ZA,et al.Expression of the androgen receptor,pAkt,and pPTEN in breast cancer and their potential in prognostication[J].Transl Oncol,2014,4(4):355-362.
[13]DE AMICIS F,THIRUGNANSAMPANTHAN J,CUI Y,et al.Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells[J].Breast Cancer Research and Treatment,2010,121(1):1-11.
[14]SALVI S,BONAFE M,BRAVACCINI S.Androgen receptor in breast cancer:A wolf in sheep's clothing? A lesson from prostate cancer[J].Semin Cancer Biol,2020,60:132-137.
[15]CLAESSENS F,DENAYER S,VAN TILBORGH N,et al.Diverse roles of androgen receptor(AR) domains in AR-mediated signaling[J].Nuclear Receptor Signaling,2018,6(1):6008-6020.
[16]NARAYANAN R,DALTON JT.Androgen receptor:A complex therapeutic target for breast cancer[J].Cancers(Basel),2016,8(12):108-124.
[17]TAN MH,LI J,XU HE,et al.Androgen receptor:Structure,role in prostate cancer and drug discovery[J].Acta Pharmacol Sin,2015,36(1):3-23.
[18]PIETRI E,CONTEDUCA V,ANDREIS D,et al.Androgen receptor signaling pathways as a target for breast cancer treatment[J].Endocr Relat Cancer,2016,23(10):485-498.
[19]ANESTIS A,ZOI I,PAPAVASSILIOU AG,et al.Androgen receptor in breast cancer-clinical and preclinical research insights[J].Molecules,2020,25(2):358-368.
[20]VASILIOU SK,DIAMANDIS EP.Androgen receptor:A promising therapeutic target in breast cancer[J].Crit Rev Clin Lab Sci,2019,56(3):200-223.
[21]CHOI JE,KANG SH,LEE SJ,et al.Androgen receptor expression predicts decreased survival in early stage triple-negative breast Cancer[J].Annals of Surgical Oncology,2015,22(1):82-89.
[22]LIM E,NI M,CAO S,et al.Importance of breast cancer subtype in the development of androgen receptor directed therapy[J].Curr Breast Cancer Rep,2014,6(2):71-78.
[23]CHIA K,O' BRIEN M,BROWN M,et al.Targeting the androgen receptor in breast cancer[J].Curr Oncol Rep,2015,17(2):4-16.
[24]BASILE D,CINAUSERO M,IACONO D,et al.Androgen receptor in estrogen receptor positive breast cancer:Beyond expression[J].Cancer Treatment Reviews,2017,61:15-22.
[25]LANZINO M,DE AMICIS F,MCPHAUL MJ,et al.Endogenous coactivator ARA70 interacts with estrogen receptor alpha(ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells[J].J Biol Chem,2005,280(21):20421-20430.
[26]DE AMICIS F,THIRUGNANSAMPANTHAN J,CUI Y,et al.Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells[J].Breast Cancer Research and Treatment,2010,121(1):1-11.
[27]CIUPEK A,RECHOUM Y,GU G,et al.Androgen receptor promotes tamoxifen agonist activity by activation of EGFR in ERα-positive breast cancer[J].Breast Cancer Research and Treatment,2015,154(2):225-237.
[28]COCHRANE DR,BERNALES S,JACOBSEN BM,et al.Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide[J].Breast Cancer Research,2014,16(1):7-25.
[29]CAO L,XIANG G,LIU F,et al.A high AR∶ERalpha or PDEF∶ERalpha ratio predicts a sub-optimal response to tamoxifen therapy in ERalpha-positive breast cancer[J].Cancer Chemother Pharmacol,2019,84(3):609-620.
[30]CREEVEY L,BLEACH R,MADDEN SF,et al.Altered steroid milieu in AI-resistant breast cancer facilitates AR mediated gene-expression associated with poor response to therapy[J].Mol Cancer Ther,2019,18(10):1731-1743.
[31]TAKAGI K,MIKI Y,NAGASAKI S,et al.Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment[J].Endocrine-Related Cancer,2010,17(2):415-430.
[32]HANAMURA T,NIWA T,NISHIKAWA S,et al.Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism[J].Breast Cancer Research and Treatment,2013,139(3):731-740.
[33]RECHOUM Y,ROVITO D,IACOPETTA D,et al.AR collaborates with ERα in aromatase inhibitor-resistant breast cancer[J].Breast Cancer Research and Treatment,2014,147(3):473-485.
[34]AMARAL C,AUGUSTO TV,ALMADA M,et al.The potential clinical benefit of targeting androgen receptor(AR) in estrogen-receptor positive breast cancer cells treated with exemestane[J].Biochim Biophys Acta Mol Basis Dis,2020,1866(5):165661-165673.
[35]I KROP VAMC.Results from a randomized placebo-controlled phase 2 trial evaluating exemestane±enzalutamide in patients with hormone receptor-positive breast cancer[J].Cancer Research,2018,78(4):4-7.
[36]ELEBRO K,BORGQUIST S,SIMONSSON M,et al.Combined androgen and estrogen receptor status in breast cancer:Treatment prediction and prognosis in a population-based prospective cohort[J].Clinical Cancer Research,2015,21(16):3640-3650.
[37]ALI A,CREEVEY L,HAO Y,et al.Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer[J].Breast Cancer Research,2015,17(1):123-141.
[38]KRABY MR,VALLA M,OPDAHL S,et al.The prognostic value of androgen receptors in breast cancer subtypes[J].Breast Cancer Res Treat,2018,172(2):283-296.
[39]VERA-BADILLO FE,TEMPLETON AJ,DE GOUVEIA P,et al.Androgen receptor expression and outcomes in early breast cancer:A systematic review and meta-analysis[J].J Natl Cancer Inst,2014,106(1):319-329.
[40]QU Q,MAO Y,FEI XC,et al.The impact of androgen receptor expression on breast cancer survival:A retrospective study and meta-analysis[J].PLoS One,2013,8(12):82650-82657.
[41]VENEMA CM,BENSE RD,STEENBRUGGEN TG,et al.Consideration of breast cancer subtype in targeting the androgen receptor[J].Pharmacology & Therapeutics,2019,200:135-147.
[42]ELEBRO K,BORGQUIST S,SIMONSSON M,et al.Combined androgen and estrogen receptor status in breast cancer:Treatment prediction and prognosis in a population-based prospective cohort[J].Clin Cancer Res,2015,21(16):3640-3650.
[43]RANGEL N,RONDON-LAGOS M,ANNARATONE L,et al.The role of the AR/ER ratio in ER-positive breast cancer patients[J].Endocr Relat Cancer,2018,25(3):163-172.
[44]PARK S,PARK HS,KOO JS,et al.Higher expression of androgen receptor is a significant predictor for better endocrine-responsiveness in estrogen receptor-positive breast cancers[J].Breast Cancer Research and Treatment,2012,133(1):311-320.
[45]HIlBORN E,GACIC J,FORNANDER T,et al.Androgen receptor expression predicts beneficial tamoxifen response in oestrogen receptor-α-negative breast cancer[J].British Journal of Cancer,2016,114(3):248-255.
[46]BRONTE G,ROCCA A,RAVAIOLI S,et al.Androgen receptor in advanced breast cancer:Is it useful to predict the efficacy of anti-estrogen therapy[J].BMC Cancer,2018,18(1):348-355.
[47]KENSLER KH,REGAN MM,HENG YJ,et al.Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer:Results from the Breast International Group Trial 1-98[J].Breast Cancer Research,2019,21(1):30-40.
[48]ACETO N,BARDIA A,WITTNER BS,et al.AR Expression in breast cancer CTCs associates with bone metastases[J].Mol Cancer Res,2018,16(4):720-727.
[49]DE LAERE B,VAN DAM PJ,WHITINGTON T,et al.Comprehensive profiling of the androgen receptor in liquid biopsies from castration-resistant prostate cancer reveals novel intra-AR structural variation and splice variant expression patterns[J].Eur Urol,2017,72(2):192-200.