|Table of Contents|

Advances in research of PD-1/PD-L1 mediated tumor immune escape in tumor microenvironment

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
520-523
Research Field:
Publishing date:

Info

Title:
Advances in research of PD-1/PD-L1 mediated tumor immune escape in tumor microenvironment
Author(s):
ZHAO TingtingZHANG Qingyuan
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000,China.
Keywords:
tumor immune escapePD-1PD-L1tumor microenvironmentinflammatory factors
PACS:
R730
DOI:
DOI:10.3969/j.issn.1672-4992.2021.03.036
Abstract:
Tumor immune escape plays a vital role in the occurrence and development of tumors.In recent years,tumor immunosuppression has become a study hotspot as one of the important mechanisms of tumor immune escape.The PD-1/PD-L1 signaling pathway,a crucial part of tumor immunosuppression,exerts the greatly effect in inhibiting the activation of T lymphocyte and increasing the immune tolerance of tumor cells,thereby achieving tumor immune escape.Therefore,targeting the PD-1/PD-L1 pathway is an important strategy for the cancer treatment.In this review,the regulatory mechanisms of the PD-1/PD-L1 signaling pathway in the tumor microenvironment and their role in mediating tumor escape are summarized.

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Last Update: 2021-01-02