|Table of Contents|

The expression of EphB2 in left-side and right-side colon cancer tissues and its correlation with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
451-454
Research Field:
Publishing date:

Info

Title:
The expression of EphB2 in left-side and right-side colon cancer tissues and its correlation with prognosis
Author(s):
HU YongweiSHEN XiaojunHAN WeiCAO FangDING HouzhongCHEN ZaichangLU Weijie
Department of General Surgery,Kunshan Hospital Affiliated to Jiangsu University,Jiangsu Kunshan 215300,China.
Keywords:
EphB2colon cancerprognosis
PACS:
R735.35
DOI:
10.3969/j.issn.1672-4992.2021.03.019
Abstract:
Objective:To investigate the expression of EphB2 protein in human colon cancer tissues,we compared the expression of EphB2 protein between left colon cancer(LCC) and right colon cancer(RCC) tissues and analyzed its prognostic value.Methods:180 cases of colon cancer specimens were selected for radical resection in Kunshan Hospital Affiliated to Jiangsu University.Immunohistochemistry was used to detect the expression of EphB2 protein in colon cancer tissues and para-carcinoma tissues,and the pathological parameters and prognosis were analyzed.Results:In the LCC tissues,EphB2 was negatively correlated with histological grade,lymph node metastasis and Dukes stage.EphB2 protein expression was not related to age,gender,histological type,tumor size,histological grade,lymph node metastasis and Dukes stage in RCC tissues.The 5-year survival rate of LCC was significantly higher than that of RCC.Although EphB2 expression was not related to 5-year overall survival(OS) in all patients or patients with RCC.Low level of EphB2 in the LCC patients predicted poor prognosis.Conclusion:In the LCC and RCC tissues,EphB2 was negatively correlated with histological grade,lymph node metastasis and Dukes stage.Low level of EphB2 in the LCC patients predicted poor prognosis.

References:

[1]BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[2]ZHANG C,ZHANG C,WANG Q,et al.Differences in stage of cancer at diagnosis,treatment,and survival by race and ethnicity among leading cancer types[J].JAMA Netw Open,2020,3(4):e202950.
[3]KHELWATTY SA,ESSAPEN S,SEDDON AM,et al.Prognostic significance and targeting of HER family in colorectal cancer[J].Front Biosci(Landmark Ed),2013,18:394-421.
[4]SONG Y,WANG L,RAN W,et al.Effect of tumor location on clinicopathological and molecular markers in colorectal cancer in eastern China patients:An analysis of 2 356 cases[J].Front Genet,2020,11:96.
[5]OGAWA K,SAEKI N,IGURA Y,et al.Complementary expression and repulsive signaling suggest that EphB2 and Ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach[J].Histochem Cell Biol,2013,140:659-675.
[6]OGAWA K,TAKEMOTO N,ISHII M,et al.Complementary expression and repulsive signaling suggest that EphB receptors and Ephrin-B ligands control cell positioning in the gastric epithelium[J].Histochem Cell Biol,2011,136:617-636.
[7]DAVALOS V,DOPESO H,VELHO S,et al.High EphB2 mutation rate in gastric but not endometrial tumors with microsatellite instability[J].Oncogene,2007,26:308-311.
[8]MIYAZAKI K,INOKUCHI M,TAKAGI Y,et al.EphA4 is a prognostic factor in gastric cancer[J].BMC Clin Pathol,2013,13:19.
[9]NAKAMURA R,KATAOKA H,SATO N,et al.EphA2/EFNA1 expression in human gastric cancer[J].Cancer Sci,2005,96:42-47.
[10]王永占,高青.EphB2在结肠癌组织中的表达及其与血管生成的关系[J].癌变?畸变?突变,2008,20(04):308-311. WANG YZ,GAO Q.Expression of EphB2 in color carcinoma and its relationship with angiogenesis[J].Carcinogenesis,Teratogenesis and Mutagenesis,2008,20(04):308-311.
[11]MALDONADO V,MELENDEZ-ZAJGLA J.Role of Bcl-3 in solid tumors[J].Mol Cancer,2011,10:152.
[12]PUVVADA SD,FUNKHOUSER WK,GREENE K,et al.NF-κB and Bcl-3 activation are prognostic in metastatic colorectal cancer[J].Oncology,2010,78(3/4):181-188.
[13]BROWN JC,ZHANG S,OU FS,et al.Diabetes and clinical outcome in patients with metastatic colorectal cancer:Calgb 80405(Alliance)[J].JNCI Cancer Spectr,2019,4(1):pkz078.
[14]URBAN BC,COLLARD TJ,EAGLE CJ,et al.BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling[J].Gut,2016,65(7):1151-1164.
[15]THAMKACHY R,KUMAR R,RAJASEKHARAN KN,et al.ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models:Efficiency of DAT1 in Ras-Raf mutated cells[J].Mol Cancer,2016,8(15):22.

Memo

Memo:
昆山市社会发展科技计划项目(编号:KS1654);江苏大学医学临床科技发展基金项目(编号:JLY20160041)
Last Update: 2020-12-31