|Table of Contents|

Effects of down-regulated far upstream element-biding protein 1 expression on migration and invasion of pancreatic cancer cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
381-384
Research Field:
Publishing date:

Info

Title:
Effects of down-regulated far upstream element-biding protein 1 expression on migration and invasion of pancreatic cancer cells
Author(s):
ZHANG Xingxing1; ZHANG Yue2; LI Huiqin1; YANG Juanli1; HE Lei1; CHEN Jinlian1; 2
1.Department of Gastroenterology，Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Compus，Shanghai 201499，China;2.Department of Gastroenterology，Anhui University of Science and Technology Affiliated Fengxian Hospital，Shanghai 201499，China.
Keywords:
far upstream element-biding protein 1; pancreatic cancer; proliferation; migration and invasion
PACS:
R735.9
DOI:
10.3969/j.issn.1672-4992.2021.03.004
Abstract:
Objective：To study the effects of down-regulated far upstream element-biding protein 1 （FUBP1） expression on proliferation，migration and invasion of pancreatic cancer cells.Methods：FUBP1 interference sequence was transfected into pancreatic cancer cell line PaTu8988 in vitro，and the FUBP1-nc was taken as negative control.CCK-8 assay was used to detect the ability of proliferation.Wound healing assay and Transwell assay were used to detect the ability of migration and invasion. Results：Knockdown expression of FUBP1 in pancreatic cancer cell line PaTu8988 could decrease the ability of proliferation，and the number of migrated and invased cells were reduced significantly.Conclusion：Knockdown expression of FUBP1 can significantly inhibit cell proliferation，meanwhile，the ability of migration and invasion are also decreased.

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上海健康医学院种子基金项目（编号：SFP-18-22-15-002）
Last Update: 2020-12-31