|Table of Contents|

Clinical value of FeNO in predicting radiation pneumonia in lung cancer patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
1005-1011
Research Field:
Publishing date:

Info

Title:
Clinical value of FeNO in predicting radiation pneumonia in lung cancer patients
Author(s):
Lu Qiong1; Mao Jialei1; Huang Chenyang2; Dai Anwei1
1.Department of Oncology,Kunshan Hospital of Traditional Chinese Medicine,Jiangsu Kunshan 215300,China；2.The Second People's Hospital of Kunshan City,Jiangsu Kunshan 215300,China.
Keywords:
radiotherapy; radiation pneumonitis; lung cancer; exhaled nitric oxide
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.06.029
Abstract:
Objective：To observe whether the increase of nitric oxide fraction (FeNO) in lung cancer patients after radiotherapy can prompt the radiation lung injury.Methods:In this study,we assessed the relationships between FeNO variations and respiratory symptoms,CT scan changes or dose volume histogram (DVH) parameters after RT.We measured FeNO before RT,4,5,6,10 weeks,4 and 7.5 months after RT in 65 lung cancer patients.Results:Eleven lung cancer patients (17%) complained of significant respiratory symptoms and 21(32%) had radiation pneumonitis images in >1/3 of the irradiated lung after RT.Thirteen patients (20%) showed increases in FeNO>10 ppb.The sensitivity and specificity of a >10 ppb FeNO increase for the diagnosis of RT-associated respiratory symptoms were 18% and 83%,respectively.There was no correlation between DVH parameters or CT scan changes after RT and FeNO variations.Three patients (5%) showed intriguingly strong (2 or 3-fold,up to 55 ppb) and sustained increases in FeNO at 4 and 5 weeks,followed by significant respiratory symptoms and/or radiation-pneumonitis images.Conclusion:Serial FeNO measurements during RT have a low ability to identify lung cancer patients who develop symptoms or images of radiation pneumonitis.However,three patients presented with a particular pattern which deserves to be investigated.

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Last Update: 2020-01-21