|Table of Contents|

Clinical value of serum Orexin A,ALB and Leptin levels in predicting malnutrition in gastrointestinal tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
976-980
Research Field:
Publishing date:

Info

Title:
Clinical value of serum Orexin A,ALB and Leptin levels in predicting malnutrition in gastrointestinal tumors
Author(s):
Sun JianghuaQin XiaohuiLiu Yuliang
General Surgery Department,the First Hospital of Handan City,Hebei Handan 056001,China.
Keywords:
cytokinesgastrointestinal tumorsmalnutritionprediction
PACS:
R735.2;R735.3
DOI:
10.3969/j.issn.1672-4992.2020.06.022
Abstract:
Objective:To analyze the correlation between serum levels of cytokines Orexin A,ALB and Leptin and gastrointestinal tumor malnutrition,and to provide evidence for clinical nutritional status assessment.Methods:A retrospective analysis of 124 patients with gastrointestinal tumors who were hospitalized in our hospital from March 2016 to December 2017 was performed.The PG-SGA scoring system was used to evaluate the nutritional status of patients and their serum.The levels of cytokines such as Orexin A,ALB,Leptin and TNF-α were detected by biochemical tests.Logistic regression was used to analyze the related factors of gastrointestinal tumor nutrition.Results:According to the PG-SGA score,43 patients with grade A (good nutritional status),59 patients with grade B (moderate or suspected malnutrition),and 22 patients with grade C (severe malnutrition).The proportion of malnourished patients was 65.32%.In the univariate analysis,the age of patients,serum levels of Orexin A,ALB,TNF-α and Leptin were related to nutritional status (P<0.05).Logistic regression analysis showed that patients had serum Orexin A (OR=1.075,95%CI:1.025~1.126),ALB (OR=0.932,95%CI:0.681~1.276),Leptin (OR=2.077,95%CI:2.009~2.148).The content of was related to the nutritional status.ROC curve analysis showed that Orexin A (AUG=0.708),ALB (AUG=0.791) and Leptin (AUG=0.592) levels were all predictive of malnutrition in patients with gastrointestinal cancer and could be used as a joint diagnosis.Conclusion:Serum levels of Orexin A,ALB and Leptin are associated with gastrointestinal tumor malnutrition and can be used for the prediction of clinical malnutrition.

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邯郸市科学技术研究与发展计划项目(编号:1323108137)
Last Update: 2020-01-21